A novel single-stranded DNA-specific 3′–5′ exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways [PDF]
Single-stranded DNA (ssDNA)-specific exonucleases (ssExos) are expected to be involved in a variety of DNA repair pathways corresponding to their cleavage polarities; however, the relationship between the cleavage polarity and the respective DNA repair ...
Agari+78 more
core +2 more sources
Identification of a new family of putative PD-(D/E)XK nucleases with unusual phylogenomic distribution and a new type of the active site [PDF]
BACKGROUND: Prediction of structure and function for uncharacterized protein families by identification of evolutionary links to characterized families and known structures is one of the cornerstones of genomics.
Bujnicki, Janusz M, Feder, Marcin
core +2 more sources
CME liftoff with high-frequency fragmented type II burst emission [PDF]
Aims: Solar radio type II bursts are rarely seen at frequencies higher than a few hundred MHz. Since metric type II bursts are thought to be signatures of propagating shock waves, it is of interest to know how these shocks, and the type II bursts, are formed. In particular, how are high-frequency, fragmented type II bursts created?
arxiv +1 more source
METTL3 Modulates Radiation‐Induced Cardiac Fibrosis via the Akt/mTOR Pathway
This study demonstrates that X‐ray radiation induces upregulation of METTL3 in mouse hearts, which is associated with reduced cardiac function and exacerbated cardiac fibrosis. X‐irradiation significantly elevates α‐SMA, Collagen I, and TGF‐β1 levels, with METTL3 knockdown mitigating this effect and attenuating X‐irradiation‐induced fibrosis.
Shunsong Qiao+6 more
wiley +1 more source
COELENTERATE TOXINS, ITS PHARMACEUTICAL AND THERAPEUTIC EFFECTS [PDF]
Present review article emphasizes species specific coelenterate toxins, its pharmaceutical and therapeutic effects. Most of the coelenterates inflict venom accidently by using nematocysts found on arms.
SHARMA, SIMRAN, UPADHYAY, RAVI KANT
core +1 more source
Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou+17 more
wiley +1 more source
Studies of the Phosphorylation of the Herpes Simplex Virus Type 1 Encoded Deoxyribonuclease and Ribonucleotide Reductase [PDF]
The herpes virus, herpes simplex type 1 (HSV-1) contains around 70 genes, most of which are expressed during lytic infection of BHK cells in culture. Two of the enzymes encoded by herpes simplex type 1 were studied using enzymatic, electrophoretic and ...
Harvie, Douglas George
core
Type-II Matrices and Combinatorial Structures [PDF]
Type-II matrices are a class of matrices used by Jones in his work on spin models. In this paper we show that type-II matrices arise naturally in connection with some interesting combinatorial and geometric structures.
arxiv
Major differences between Candidatus Altiarchaeum species living in two distinct subsurface ecosystems as determined via metatranscriptomics. Genes overly expressed in different Ca. Altiarchaea in Muehlbacher sufidic spring (magenta; MSI; Regensburg, Germany) and Crystal Geyser (turquise; CG; Utah, USA). Ca.
Sarah P. Esser+9 more
wiley +1 more source
Breed differences in PCV2 uptake and disintegration in porcine monocytes [PDF]
Porcine circovirus type 2 (PCV2) is associated with various diseases which are designated as PCV2-associated diseases (PCVADs). Their severity varies among breeds.
Huang, Liping+4 more
core +2 more sources