Results 101 to 110 of about 222,705 (339)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Psicologia em Estudo, 2003 Este estudo tem como objetivo avaliar a fidedignidade da Escala de Condutas Anti-sociais e Delitivas ou Delinqüente (Seidedos, 1988) para outros contextos brasileiros, a partir de um parâmetro psicométrico, o Alpha de Cronbach.
Nilton Soares Formiga
doaj +1 more source
Validation of Ultrahigh Dependability for Software-Based Systems [PDF]
, 1993 Modern society depends on computers for a number of critical tasks in which failure can have very high costs. As a consequence, high levels of dependability (reliability, safety, etc.) are required from such computers, including their software.
Barwise J +10 more
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
ComputersThis paper proposes an integrated ontological framework, Integrated Systems Ontology (ISOnto), for dependable systems engineering by semantically linking design models with real-world operational failure data. Building upon the recently proposed Function–
Haytham Younus +4 more
doaj +1 more source
Autoencoder-Based Semantic Novelty Detection: Towards Dependable AI-Based Systems
, 2021 Andreas Rausch +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Application progress of SGX in trusted computing area
网络与信息安全学报, 2021 The trusted computing technology SGX protects the confidentiality and integrity of key codes and data by isolating a trusted execution environment, which can help prevent all kinds of attacks.Firstly, the research background and working principle of SGX ...
Bo ZHAO, Anqi YUAN, Yang AN
doaj
Argument Representation for Dependable Computer-Based Systems
Informal Logic, 2001 Society is becoming increasingly reliant upon the dependability of computerbased systems. Achieving and demonstrating the dependability of systems requires the construction and review of valid and coherent arguments.
C. Gurr
doaj +1 more source
Empirical evaluation of accuracy of mathematical software used for availability assessment of fault-tolerant computer systems [PDF]
, 2012 Dependability assessment is typically based on complex probabilistic models. Markov and semi-Markov models are widely used to model dependability of complex hardware/software architectures.
Kharchenko, V. S. +3 more
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