Results 121 to 130 of about 279,947 (331)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Enhancing the EAST-ADL error model with HiP-HOPS semantics [PDF]

, 2014
EAST-ADL is a domain-specific modelling language for the engineering of automotive embedded systems. The language has abstractions that enable engineers to capture a variety of information about design in the course of the lifecycle — from requirements ...
Chen, De-Jiu, Lönn, Henrik, Papadopoulos, Yiannis, Sharvia, Septavera, Walker, Martin, Yuan, Wenjing   +5 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Sensing as a Service Reinvented: A Unified and Sustainable Sensing Framework for Smart X Development

IEEE Access
This paper introduces a Unified and Sustainable Sensing as a Service (USSenaaS) framework that integrates Internet of Things (IoT) technologies and Sensing as a Service (SenaaS) to enhance the efficiency, scalability, and sustainability of Smart-X ...
Mindit Eriyadi, Suhono Harso Supangkat, Fadhil Hidayat   +2 more
doaj   +1 more source

Generalisation of availability models for resilient systems with online verification [PDF]

International Journal of Electronics and Telecommunications
This paper analyses online verification methods for safety- and security-critical systems, including aerospace, nuclear instrumentation, and smart home systems.
Vyacheslav Kharchenko, Yuriy Ponochovnyi, Oleksandr Ivasiuk, Oleg Illiashenko, Olena Ponochovna   +4 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

An interdisciplinary perspective of dependability in Open Source Software [PDF]

, 2004
Open Source Software (OSS) development needs to be considered during software development as to whether to develop an OSS packages, and/or whether to develop with OSS.
Gacek, C.
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Data Dependence [PDF]

Review, 2007
A speech at the Middle Tennessee State University, Annual Economic Outlook Conference, Murfreesboro, Tenn., Sept.
openaire   +3 more sources