Results 111 to 120 of about 4,975,318 (340)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Global compilation of double seismic zones and their dependence on the intraslab stress field

open access: gold, 2022
Christian Sippl   +3 more
openalex   +1 more source

Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement

open access: yesThe Scientific World Journal, 2008
The conditioned place preference (CPP) model has been widely used to evaluate the rewarding effects of abused drugs, and recently, the extinction and reinstatement phases of this paradigm have been used to assess relapse to drug seeking.
Yu Liu   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Relapse Among Patients Referring to Residential Rehabilitation Centers for Drug Use Disorders in Iran and Its Related Factors

open access: yesIranian Rehabilitation Journal, 2018
Objectives: In this study, we aimed to determine the individual characteristics of clients who were referred to residential rehabilitation centers for drug use disorders and to determine their relapse-related factors.
Omid Massah   +4 more
doaj  

Effects of cue-synchronized parietal cathodal tDCS on internet gaming disorder: A randomized double-blind sham-controlled trial

open access: yesBrain Stimulation
Background and objectives: Internet Gaming Disorder (IGD) is prevalent with limited treatment efficacy. Targeting reducing craving triggered by gaming cues is a critical therapeutic objective.
Yixuan Song   +12 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Developing the Guideline of Therapeutic Interventions for Street Children With Substance Use Disorders

open access: yesIranian Rehabilitation Journal, 2018
Millions of children are left to survive on the streets around the world. Investigations on drug use disorders among street children reveal that they not only abuse all types of drugs higher than their peers who live at home or in shelters, but also they
Nastaran Habibi   +11 more
doaj   +2 more sources

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