Results 141 to 150 of about 4,975,318 (340)

Clinical Characteristics of Patients With Cannabis‐Related Mental Disorders and an Examination of Factors Influencing Their Access to Medical and Nonmedical Resources: Comparison of Methamphetamine‐Related Mental Disorders

open access: yesNeuropsychopharmacology Reports
Purpose This study aims to identify the characteristics of patients with cannabis use disorder and to determine whether the challenges in treating cannabis use disorder stem from the pharmacological properties of cannabis as an abused substance or from ...
Toshihiko Matsumoto   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Therapeutic Community Effectiveness on Self-Esteem and Relapse Rate among Drug Users

open access: yesJournal of Rehabilitation, 2012
Objective: In recent years, the Therapeutic Community(TC) has become a widespread treatment alternative for drug addicts. TC have been widely studied with emphasis on thair effectiveness.
Mosayyeb Yarmohammadi-Vasel   +3 more
doaj  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Functional evaluation of NK1 antagonism on cue reactivity in opiate dependence; An fMRI study

open access: hybrid, 2021
Leon Fonville   +6 more
openalex   +1 more source

The impact of REM sleep loss on human brain connectivity

open access: yesTranslational Psychiatry
Brain function is vulnerable to the consequences of inadequate sleep, an adverse trend that is increasingly prevalent. The REM sleep phase has been implicated in coordinating various brain structures and is hypothesized to have potential links to brain ...
Tianqi Di   +11 more
doaj   +1 more source

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