Results 231 to 240 of about 4,975,318 (340)

Accurate Determination of the Temperature Sensitivity of UV-Induced Fiber Bragg Gratings. [PDF]

Sensors (Basel)
Cosme M, Pota M, Preizal J, Caldas P, Oliveira R, Nogueira R, Araújo FM, Cruz JL, Rego GM.   +8 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Assessment of cognitive functions in patients with alcohol dependence disorder and its implications for primary care: A cross-sectional study. [PDF]

J Family Med Prim Care
Shah K, Niranjan V, Mathur R, Prasad S.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Structure-Dependence and Mechanistic Insights into the Piezoelectric Effect in Ionic Liquids

Md. Iqbal Hossain, Haozhe Wang, Laxmi Adhikari, Gary A. Baker, Andrea Mezzetta, Lorenzo Guazzelli, Patrizia R. Mussini, Weiwei Xie, G. J. Blanchard   +8 more
openalex   +1 more source

Study on the policy implementation of the Guangdong-Hong Kong-Macao joint graduate training program and regional talent development. [PDF]

PLoS One
Li S, Lam JFI.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The 2019 national health survey: what does it teach us about the epidemiological profile of stroke in Brazil? [PDF]

BMC Public Health
de Oliveira Baggio JA, do Nascimento BRL, Suassuna AF, Andrade LA, Bezerra-Santos M, de Almeida Rocha LJ.   +5 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Low family support perception: a ‘social marker’ of substance dependence?

, 2012
Valdir de Aquino Lemos, Hanna Karen Moreira Antunes, Makilim Nunes Baptista, Sérgio Tufik, Marco Túlio de Mello, Maria Lúcia Oliveira de Souza Formigoni   +5 more
openalex   +1 more source