Results 201 to 210 of about 9,392,573 (389)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A simple measure of dependence
This master thesis presents two consecutive measures to quantify the degree of regression dependence. In the first part, Azadkia and Chatterjee's Rank Correlation T is analyzed, which measures the degree of predictability between a one-dimensional random
Wurzer, Jakob
core +1 more source
Measuring Dependence with Matrix-based Entropy Functional
, 2021 Shujian Yu +4 more
openalex +2 more sources
Market orientation in the non-profit sector: a resource dependence perspective [PDF]
In the context of an increasingly competitive environment in which organisations are compelled to manage their resources and capabilities in more efficient and effective ways, the concept of market orientation has been acknowledged as highly important in
Isabel Maria Macedo, José Carlos Pinho
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Symmetric Rank Covariances: a Generalised Framework for Nonparametric Measures of Dependence [PDF]
, 2017 Luca Weihs +2 more
openalex +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source