Results 91 to 100 of about 32,006,081 (306)

Dependency Networks for Relational Data

open access: yesFourth IEEE International Conference on Data Mining (ICDM'04), 2005
Instance independence is a critical assumption of traditional machine learning methods contradicted by many relational datasets. For example, in scientific literature datasets, there are dependencies among the references of a paper. Recent work on graphical models for relational data has demonstrated significant performance gains for models that ...
Jennifer Neville, David D. Jensen
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Generación de tiempos de falla dependientes Weibull bivariados usando cópulas

open access: yesRevista Colombiana de Estadística, 2008
La distribución Weibull bivariada es muy importante en confiabilidad y en análisis de supervivencia. La dependencia para este tipo de problemas ha venido cobrando gran importancia en años recientes.
MARIO CÉSAR JARAMILLO   +3 more
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

GENERATION OF WEIBULL BIVARIATE DEPENDENT FAILURE TIMES USING COPULAS GENERACIÓN DE TIEMPOS DE FALLA DEPENDIENTES WEIBULL BIVARIADOS USANDO CÓPULAS

open access: yesRevista Colombiana de Estadística, 2008
The bivariate Weibull distribution is very important in both reliability and survival analysis. The dependence for these kind of problems has been gaining great importance in recent years.
Jaramillo Mario César   +3 more
doaj  

A Dependent Bivariate Burr XII Inverse Weibull Model: Application to Diabetic Retinopathy and Dependent Competing Risks Data

open access: yesMathematics
This paper introduces a novel bivariate distribution, referred to as the Bivariate Burr XII Inverse Weibull (BBXII-IW) distribution, constructed via the Marshall–Olkin approach from the univariate Burr XII Inverse Weibull (BXII-IW) distribution.
Ammar M. Sarhan   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Data Quality Is Context Dependent [PDF]

open access: yes, 2011
We motivate, formalize and investigate the notions of data quality assessment and data quality query answering as context dependent activities. Contexts for the assessment and usage of a data source at hand are modeled as collections of external databases, that can be materialized or virtual, and mappings within the collections and with the data source
Leopoldo E. Bertossi   +2 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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