Results 221 to 230 of about 32,006,081 (306)

Climatic Influence on COVID-19: Investigating the Role of Temperature and Humidity in the Spread of the Omicron Variant. [PDF]

Geohealth
López L, Fontal A, Alfaro B, Rodó X.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Serofast Syphilis Is Associated with Phospholipid-Dependent Coagulation Abnormalities and B-Cell Activation Following Treatment. [PDF]

Int J Mol Sci
Kiolbasa M, Kaminiow K, Kadylak D, Pastuszczak M.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

An approach for estimating thermoelectric module equivalent properties by thermal resistance and numerical modeling. [PDF]

iScience
Pham MQ, Nguyen VL, Vo TQ, Hong TD.
europepmc   +1 more source

Atrial Tachycardia Utilizing Bachmann's Bundle as an Epicardial Bypass: A Case Suggestive of a Dual-Loop Mechanism. [PDF]

Ann Noninvasive Electrocardiol
Sakurai R, Nakatani Y, Fujiwara K, Miyamoto T.   +3 more
europepmc   +1 more source

Conformational Fingerprints Underlying Thermal Modulation of PAC/TMEM206 Gating. [PDF]

Int J Mol Sci
Reyes-Lizana R, Fernández G, Duran-Morales S, Carrasco-Faus G, Duarte Y, Marquez-Miranda V, Díaz-Franulic I.   +6 more
europepmc   +1 more source

Synthetic Expansion of Blood Dielectric Spectra at Microwave Frequencies Using Data-Driven Methods. [PDF]

Sensors (Basel)
Alhummada I, Bialkowski A, Guo L, Villena Gonzales W, Deriche M, Abbosh A.   +5 more
europepmc   +1 more source

Metabolic Mechanisms of Neutrophil Phagocytic Activity in Patients with Widespread Purulent Peritonitis Bacterial Peritonitis Before and After Surgery. [PDF]

Int J Mol Sci
Savchenko AA, Kudlay D, Gvozdev II, Anisimova EN, Cherdantsev DV, Kudryavtsev I, Rubinstein A, Starshinova AA, Borisov A.   +8 more
europepmc   +1 more source