Results 241 to 250 of about 29,845,221 (313)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition. [PDF]

PLoS Genet
Khan C, Rusan NM, Baker NE.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Proteomic Profile Differences in Immune-Related Diseases in Pediatric Patients Under Five Years Old: Asthma and IgE-Dependent Allergies-A Pilot Study. [PDF]

Int J Mol Sci
Rzetecka-Mańka N, Matysiak J, Matuszewska-Mach E, Sobkowiak P, Wojsyk-Banaszak I, Bręborowicz A, Borysewicz P, Klupczyńska-Gabryszak A, Matysiak J.   +8 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Discovery of Ro 41-0960, a Non-Steroidal Inhibitor of the Na⁺/K⁺-ATPase. [PDF]

ChemMedChem
Cruz-Cortés C, Šeflová J, Guerrero-Serna G, Jimenez-Vazquez EN, Anumonwo J, Espinoza-Fonseca LM.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Inflammation Meets Ventricular Dynamics: Combined Hematologic and Radiologic Predictors of Shunt-Dependent Hydrocephalus in Endovascularly Treated Patients with Aneurysmal Subarachnoid Hemorrhage. [PDF]

Diagnostics (Basel)
Arslan A, Boga Z, Olguner SK, Sürmelioğlu ZN, Sarac ME, Ozer M, Harmanoğullarından A, Sürmelioğlu A, Acik V, Gezercan Y.   +9 more
europepmc   +1 more source

Scattering properties of Intralipid modeled using dependent scattering theory. [PDF]

J Biomed Opt
Attendu X, de Sivry-Houle MP, Shahsavari M, Faber DJ, van der Pol E, van Leeuwen TG.   +5 more
europepmc   +1 more source