Results 181 to 190 of about 302,258 (333)

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Artificial intelligence-enabled "inherited noninvasive intracellular recording" for prolonged monitoring of cardiac action potentials. [PDF]

Sci Adv
Liu S, Xu X, Cai Y, Yao C, Liu Z, Hou L, Li M, Li X, Li Y, Li G, Li M, Huang S, Huang X, Chen X, Wang J, Liu J, Chen HJ, Xie X.   +17 more
europepmc   +1 more source

Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons

, 2009
Geraldine J. Kress, Margaret J. Dowling, Lawrence N. Eisenman, Steven Mennerick   +3 more
openalex   +2 more sources

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Retardance and depolarization of brain white matter as markers for intraoperative delineation of brain tumors: experiments and simulations. [PDF]

Biomed Opt Express
Wang M, Chae S, Lukinsone V, Lucas T, Rodríguez-Nuñez O, Gros É, Hahne C, Maragkou T, McKinley R, Schucht P, Novikova T.   +10 more
europepmc   +1 more source

depolarization ratio

Citation: 'depolarization ratio' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.08586 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source

A Modified Depolarization Approach for Efficient Quantum Machine Learning [PDF]

Bikram Khanal, Pablo Rivas
openalex   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

TRPV3 channel activity helps cortical neurons stay active during fever. [PDF]

Elife
Shen Y, Fiáth R, Krishnan BM, Ulbert I, Antoine MW.   +4 more
europepmc   +1 more source

TENSION COMPONENTS AND TENSION FALL OF THE BULLFROG ATRIAL MUSCLE DURING DEPOLARIZATION

, 1974
Masayosi GOTO, Yasuo Wada, Masahiko Saito   +2 more
openalex   +2 more sources