Results 191 to 200 of about 152,419 (267)

Serotonin Modulates Stellate Cell Excitability via 5-HT Receptors and HCN Channels in the Mouse Anteroventral Cochlear Nucleus. [PDF]

Int J Mol Sci
Özkaya B, Yıldırım C, Erdoğan E, Aydın MŞ, Bal R.   +4 more
europepmc   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Effect of Secondary Crosslinking Time on the Interfacial Insulation Performance of Crosslinked Polyethylene/Semiconductive Shielding Layer. [PDF]

Polymers (Basel)
Hu M, Zhang H, Ge X, Yan Y, Yang Y, Cao X, Li Z, Huo W.   +7 more
europepmc   +1 more source

Volatile ZrO2 Antiferroelectric Tunnel Junctions for Rapid, Energy‐Efficient Physical Reservoir Computing

Advanced Science, EarlyView.
An antiferroelectric tunnel junction serves as a reservoir computing node, where field‐induced phase transitions and spontaneous ZrO2 relaxation deliver nonlinear fading memory. An In‐Ga‐Zn oxide interlayer enlarges the memory margin and multibit state richness.
Taegyu Kwon, Moonseek Jeong, Su In Hwang, Geun Hyeong Park, Joonyong Kim, Hyojun Choi, Hyeong Seok Choi, Da Hyun Kim, Dong Hee Han, Ju Yong Park, Seungho Baek, Jung Ho Yoon, Dong Hyun Lee, Min Hyuk Park   +13 more
wiley   +1 more source

Dual Pathways Coupled to Oxytocin Molecular Signals in Cultured Astrocytes. [PDF]

Cells
Farsetti E, Amato S, Averna M, Gatta E, Guidolin D, Pedrazzi M, Lori L, Gnecco M, Maura G, Agnati LF, Marcoli M, Cervetto C.   +11 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Steric Control of Cooperative Anion Transport Mediated by β- and δ‑Hexachlorocyclohexane Multivalent Carriers. [PDF]

JACS Au
Stroia I, Oanea A, Hadade N, Grosu I, Baaden M, Barboiu M.   +5 more
europepmc   +1 more source

Increased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity. [PDF]

Mol Metab
Dell'Orco J, Pan W, Allison MB, Tomlinson AJ, Wean J, Sabatini PV, Rhodes CJ, Olson DP, Myers MG, Goforth PB.   +9 more
europepmc   +1 more source

Stochasticity in action potential backpropagation: consequences for neuronal computation. [PDF]

Front Cell Neurosci
Antic SD, Milicevic KD, Lytton WW.
europepmc   +1 more source

Comparative Pharmacological Profiling of Psychotherapeutic Drugs Reveals a Functional Taxonomy Based on Direct Inhibition of Smooth Muscle Excitability. [PDF]

Pharmaceuticals (Basel)
Castrillejo MJ, Velasco A, Mielgo-Ayuso JF, Pérez J, Garrosa M, Rodríguez-Arias CA, Fernández-Lázaro D.   +6 more
europepmc   +1 more source