Results 41 to 50 of about 14,281 (294)

Microfacies Analysis and Depositional Environment of Upper Oligocene-Lower Miocene Succession in Wadi Al-Khazgah of Anbar Governorate, Western Iraq

Iraqi Geological Journal, 2023
Microfacies and the Depositional Environment of (Upper Oligocene-Lower Miocene) succession in the Anah area, northwest of Anbar Governorate, western Iraq was carried out.
Aseel Mohammed, Amer Aljibouri
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Calcareous algae from the Ordovician succession (Thango Formation) of the Spiti Basin, Tethys Himalaya, India

Acta Palaeobotanica, 2018
The calcareous algae Dasyporella silurica, Moniliporella multipora and Vermiporella fragilis are reported for the first time from the Middle Ordovician (Dapingian to Darriwilian) Thango Formation of the Spiti Basin of northern India (Pin Valley, Tethys ...
SHIVANI PANDEY, SURAJ K. PARCHA
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Characterization of reservoirs and depositional study of J-P Field, shallow offshore of Niger Delta Basin, Nigeria

Scientific African, 2022
Well log data interpretation was carried out over J-P Field in the Niger Delta, Nigeria. This was done with a view to characterizing the reservoirs based on the estimation of petrophysical parameters and to assessing the environment of deposition in J-P ...
Theophilus Aanuoluwa Adagunodo, Oyelowo Gabriel Bayowa, Oluwaseun Emmanuel Alatise, Adeola Opeyemi Oshonaiye, Olusegun Oladotun Adewoyin, Victor Onaolamipo Opadele   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Gerakan struktur dan kaitannya dengan faktor kendali tektonik, berdasarkan analisis stratigrafi; Studi kasus geologi kuarter terhadap fase perkembangan Danau Tondano purba sepanjang Remboken - Kakas, Kec. Remboken dan Kec. Kakas, Kab. Tomohon, Sulawesi Ut

Indonesian Journal on Geoscience, 2014
http://dx.doi.org/10.17014/ijog.vol2no3.20075Studies of stratigraphy on Quaternary deposits in the southwest region of Lake Tondano, Tomohon Regency, South Sulawesi, revealed six facies of deposition environments.
Herman Moechtar, Indyo Pratomo, Herman Mulyana, Soemantri Poedjoprajitno   +3 more
doaj   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source