Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Sedimentological analysis and hydrocarbon potential of the upper devonian-lower carboniferous Tahara sandstones, ghadames basin, western Libya [PDF]
The Palaeozoic (Upper Devonian-Lower Carboniferous) Tahara Formation, western Libya, was deposited in shallow-water, marginal and nearshore marine environments influenced by waves and storms.
Burki, Milad Mohamed Milad
core
Effect of Geologic Depositional Environment on CO2 Storage Efficiency [PDF]
The storage potential and movement of fluids within a formation is dependent on hydraulic characterization unique to each depositional environment. Storage efficiency (E), the ratio of the injected volume of CO2 to the accessible pore volume, quantifies ...
Scott Frailey +5 more
core +1 more source
A sedimentological investigation was carried out in Agu-Awka and Umunya localities to interpret the facies, depositional environment, sequence stratigraphy, reservoir potential, and architecture of the outcropping Eocene Nanka Formation of the Ameki ...
Ovie B. Ogbe, Jerry Osokpor
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Sequence Stratigraphic Interpretation of XY-Field Onshore Niger Delta Basin Nigeria
Wireline logs and biostratigraphic data were integrated to attempt the sequence stratigraphy of “XY field” onshore Niger Delta Basin which revealed three depositional sequences.
C.E. Okpala +4 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Carbonate facies, diagenesis and sequence stratigraphy of an eocene nummulitic seservoir interval (jdeir formation), offshore NW Libya [PDF]
This study investigates the sedimentology, petrology and depositional environments of a major Early Eocene nummulitic reservoir unit: the Jdeir Formation, from offshore NW Libya in the Mediterranean Sea. This formation is a prolific hydrocarbon-producing
Alhnaish, Abdelhakim S.
core
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source

