Results 61 to 70 of about 96,388 (335)

Pliocene-Pleistocene marine cyclothems, Wanganui Basin, New Zealand: a lithostratigraphic framework [PDF]

, 1995
The Rangitikei River valley between Mangaweka and Vinegar Hill and the surrounding Ohingaiti region in eastern Wanganui Basin contains a late Pliocene to early Pleistocene (c. 2.6-1.7 Ma), c.
Abbott S. T., Aguirre E., Anderton P. W., Feldmeyer A. E., Fleming C. A., Milne J. D. G., Naish T. R., Pillans B., Seward D., Shackleton N. J., Stern T. A., Te Punga M. T., Vail P., Wilson G. S.   +13 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Microfacies Analysis and Depositional Environment of Upper Oligocene-Lower Miocene Succession in Wadi Al-Khazgah of Anbar Governorate, Western Iraq

Iraqi Geological Journal, 2023
Microfacies and the Depositional Environment of (Upper Oligocene-Lower Miocene) succession in the Anah area, northwest of Anbar Governorate, western Iraq was carried out.
Aseel Mohammed, Amer Aljibouri
doaj   +1 more source

Textural and compositional variations in beach sands along Karachi coast [PDF]

, 1992
The texture of clastic sediments is a fairly reliable index of the erosional history and energy conditions of the depositional environment, while its mineralogy reflects the composition of the source rocks. The beach sands of Clifton, Sandspit, Hawkesbay
Ibrahim, N., Muhammad, M.J., Zaidi, S.M.S.   +2 more
core  

Neogene stratigraphic architecture and tectonic evolution of Wanganui, King Country, and eastern Taranaki Basins, New Zealand [PDF]

, 2004
Analysis of the stratigraphic architecture of the fills of Wanganui, King Country, and eastern Taranaki Basins reveals the occurrence of five 2nd order Late Paleocene and Neogene sequences of tectonic origin.
Bland, Kyle J., Cartwright, Stuart J., Hansen, Rochelle J., Hayton, Shaun, Hendy, Austin J.W., Kamp, Peter J.J., McIntyre, Avon P., Nelson, Campbell S., Ngatai, Melodie, Vonk, Adam J.   +9 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Geomorphological classification of urban landscapes. The case study of Rome (Italy) [PDF]

, 2016
The results of a long-lasting geomorphological survey carried out in Rome are summarized. A method aimed at integrating survey data, historical maps, aerial photographs and archaeological and geomorphological literature produced a geomorphological map ...
D'Orefice, Maurizio, DEL MONTE, Maurizio, Luberti, Gian Marco, Marini, Roberta, PIca, Alessia, VERGARI, FRANCESCA   +5 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A four stage evolution of the White Channel gravel: Implications for stratigraphy and palaeoclimates [PDF]

, 2014
Although the White Channel gravel (WCG) of the Klondike district, Yukon, contains gold placers which have been exploited for over a century, few sedimentological studies have been undertaken.
Chapman, Robert, Lowther, Robert, Peakall, Jeff, Pound, Matthew   +3 more
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source