Results 41 to 50 of about 1,588,539 (338)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

SkyScan 1172 X-ray micro-CT scanner of well-core digital modeling for geophysical analysis of landscape polystructures

Geology, Ecology, and Landscapes
The present study deals with algorithms for the acquisition of a well-core digital model that is used in the Digital Well-Core technology or “Digital Petrophysics.” The study involved the initial implementation stage of this technology: identification of
Marsel A. Kadyrov, Mikhail D. Zavatsky, E. Yu Neelova, Andrey A. Ponomarev, Maksim S. Bikalenko   +4 more
doaj   +1 more source

Thermochemical oxidation of methane induced by high-valence metal oxides in a sedimentary basin

Nature Communications, 2018
The role of thermochemical oxidation of methane (TOM) by high-valence metal oxides as a potential methane sink remains poorly understood. Here, the authors present evidence of TOM induced by Mn(Fe) oxides in a sedimentary basin, which yields calcite with
Wen-Xuan Hu, Xun Kang, Jian Cao, Xiao-Lin Wang, Bin Fu, Hai-Guang Wu   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Behaviour of Rare Earth Elements in the resent Sediments of Water Plants tanks and of Domestic Water in Mosul City [PDF]

Kirkuk Journal of Science, 2017
The present study includes distribution of rare earth elements in the resent sediments of the water plants and in domestic water tanks in some areas in Mosul city.
Hazim Ameen Muhammad, Hameed Jasem Muhammad   +1 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Hydrogeochemical processes and groundwater chemistry in the West Siberia

Geology, Ecology, and Landscapes
The present study aimed to identify the formation factors of the current hydrogeochemical character of the Middle-Jurassic aquifer groundwaters (beds YU 2–4) in the Lyaminsky petroleum district of West Siberia in Russia.
Rimma N. Abdrashitova, Yulia S. Salnikova, Galina S. Bozhenkova, Andrey A. Ponomarev, Mikhail D. Zavatsky, Alena M. Bulasheva   +5 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source