Results 41 to 50 of about 276,768 (218)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Behaviour of Rare Earth Elements in the resent Sediments of Water Plants tanks and of Domestic Water in Mosul City [PDF]
Kirkuk Journal of Science, 2017 The present study includes distribution of rare earth elements in the resent sediments of the water plants and in domestic water tanks in some areas in Mosul city.
Hazim Ameen Muhammad +1 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Russian Journal of Earth SciencesThe results of a comprehensive analysis of fault tectonics of the Kola Peninsula, carried out on a regional scale, are considered. Based on a digital relief model, generalized for various scale levels, lineaments were identified manually and ...
Minaev Vasilii +4 more
doaj +1 more source
Hydrogeochemical processes and groundwater chemistry in the West Siberia
Geology, Ecology, and LandscapesThe present study aimed to identify the formation factors of the current hydrogeochemical character of the Middle-Jurassic aquifer groundwaters (beds YU 2–4) in the Lyaminsky petroleum district of West Siberia in Russia.
Rimma N. Abdrashitova +5 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Geochemistry, Geophysics, GeosystemsThe slab breakoff model is a preferred geodynamic interpretation for post‐collisional exhumation and associated magmatic flare‐ups. In this study, rutile U–Pb dating of retrograde eclogites revealed distinct stages of exhumation along the Paleo‐Tethyan ...
Min Liu +7 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source