Results 51 to 60 of about 1,588,539 (338)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Regional Remote Sensing Analysis of Fault Tectonics of the Kola Peninsula and Its Role in Ore Formation

Russian Journal of Earth Sciences
The results of a comprehensive analysis of fault tectonics of the Kola Peninsula, carried out on a regional scale, are considered. Based on a digital relief model, generalized for various scale levels, lineaments were identified manually and ...
Minaev Vasilii, Ustinov Stepan, Petrov Vladislav, Svecherevsky Alexey, Nafigin Igor   +4 more
doaj   +1 more source

Considerations on the management of banks with numerous branches in the common market countries. Variations on the theme of productivity

PSL Quarterly Review, 2014
The work is concerned with developing a general concept of productivity in banking. The study finds its origin in the simple observation that if the number of staff in large banks of different countries is divided by total balances or deposits, the ...
A. ROUX
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

INVESTMENT ATTRACTION THE DEVELOPMENT OF PEAT DEPOSITS ON THE EXAMPLE OF LENINGRAD REGION

Вестник Северо-Кавказского федерального университета, 2022
In the artikle presetet large number of unclaimed deposits ofpeat dictate the necessity to intensify their input in industrial development. Moreover, the scope of use ofpeat is very diverse and importantfor the regional economy in such branches as: small
Galina Peshkova
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

THE INFLUENCE OF GEOLOGY AND ORE DEPOSIT OCCURRENCE CONDITIONS ON DILUTION INDICATORS OF EXTRACTED RESERVES

Rudarsko-geološko-naftni Zbornik, 2019
The development of iron-ore deposits is accompanied by the excavation formation of considerable dimensions in the underground space and to ensure high technical and economic indicators of extraction, especially when developing high-grade iron ore, it is ...
Mykhailo Petlovanyi, Vasyl Lozynskyi, Serhii Zubko, Pavlo Saik, Kateryna Sai   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Natural history specimens collected and/or identified and deposited.

Ugolino Martelli
  +7 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source