Results 191 to 200 of about 31,985 (264)

The evolving epidemiology of opioid use disorder: polysubstance use, drug supply transformation, and policy implications. [PDF]

Front Public Health
Mandapati NK, Tovar DC, Bindlish R, Hernandez YL, Alves MJ, Baum MK, Aggarwal S.   +6 more
europepmc   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Pharmacological evidences for the blood pressure lowering and cardiovascular inhibitory actions of the essential oil of <i>Thymus serrulatus</i> hochst. Ex benth. [PDF]

Front Pharmacol
Rehman NU, Ansari MN, Aldossari AA, Alhatlan TA, Palla AH, Karim A, Noman M.   +6 more
europepmc   +1 more source

An On‐Demand Neuromorphic Vision System Enabled by a Multi‐Paradigm Neuromorphic Device and Hierarchical Reconfigurability Designed from Device to System Level

Advanced Science, EarlyView.
An on‐demand ultra‐reconfigurable intelligent vision system with hierarchical reconfigurability from device to system levels is demonstrated. Through co‐design of a multi‐paradigm device, reconfigurable circuits, and adaptive system architecture/algorithms, the system enables seamless switching among spiking, non‐spiking, neuromorphic imaging (NI), and
Biyi Jiang, Jiayi Xu, Liang Ran, Xinhe Feng, Khalil Harrabi, Yida Li, Longyang Lin, Feichi Zhou   +7 more
wiley   +1 more source

Xiaoyao San against depression via glia-mediated neuroinflammation using network pharmacology and experimental validation. [PDF]

Sci Rep
Liu XY, Yan YZ, Jiang AJ, He WY, Fang YY, Li CH, Deng MF, Tan SJ, Zeng P.   +8 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression. [PDF]

Adv Sci (Weinh)
Cai X, Sun T, Feng M, Chen G, Zhou J, Zhuang H, Wang D, Chen Y, Cheng Z, Xu Z, Zheng X, Zhang X, Yuan Y.   +12 more
europepmc   +1 more source

Pregabalin-associated adverse drug reactions: A real-world pharmacovigilance study using WHO-VigiAccess. [PDF]

Medicine (Baltimore)
Alshehri FS, Ashour AM, Alorfi NM, Alshehri AS, Almahdi MK, Almowallad FM.   +5 more
europepmc   +1 more source

Pain relief but respiratory depression: Insights into the dark side of opioid overuse. [PDF]

J Physiol
Zoccal DB.
europepmc   +1 more source

A meta-model of low back pain to examine collective expert knowledge of treatment effects and their mechanisms. [PDF]

Eur Spine J
Cholewicki J, Hodges PW, Popovich JM, Aminpour P, Gray SA, Lee AS, Breen A, Brumagne S, van Dieën JH, Van Dillen LR, Dreisinger TE, Ferreira ML, George SZ, Goertz CM, Hartvigsen J, Hides JA, Hoy D, Kawchuk GN, Koes BW, Kothe R, Langevin HM, Lee D, Lotz JC, Moseley GL, Prather H, Reeves NP, Sahrmann S, Smeets RJ, Stone LS, Vlaeyen JWS, Wang JC, Weiser S.   +31 more
europepmc   +1 more source