Results 61 to 70 of about 69,933 (288)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Etheropoliamide depressor additives for oil fuel fractions
Известия высших учебных заведений: Нефть и газ, 2019 Improving the low-temperature properties of oil fractions, in particular diesel fuels using depressant additives, is one of the simplest and most effective methods. The synthesis of additives based on the use of domestic industrial raw materials.
A. M. Glazunov +3 more
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Protective effect of resveratrol against corticosterone-induced neurotoxicity in PC12 cells
Translational Neuroscience, 2019 Resveratrol(RES) is a natural polyphenol which possesses an anti-depressant effect. However, the mechanisms of its anti-depressant effect remain unclear.
Zhang Ye +5 more
doaj +1 more source
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. [PDF]
, 2010 Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use ...
Bolaños, Carlos A +26 more
core +3 more sources
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Overdose Prevention and Response A guide for people who use drugs and harm reduction staff in Eastern Europe and Central Asia [PDF]
, 2009 Provides an overview of the drug overdose problem in Eastern Europe and Central Asia; describes overdose symptoms, factors that affect overdose risk, prevention methods, and step-by-step responses to an overdose.
Curtis, Matt, Guterman, Lydia
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Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
InventionsThe use of depressant additives is the most effective and cost-effective way to improve the low-temperature properties of diesel fuels, like the cloud point, cold filter plugging point and pour point.
Yana Morozova +4 more
doaj +1 more source
Beneficiation of rare earth minerals from Bokan Mountain: Dotson Ridge ore [PDF]
, 2014 Thesis (M.S.) University of Alaska Fairbanks, 2014The purpose of this research work was to study the beneficiation of rare earth ore of the Bokan Mountain -- Dotson Ridge deposit, located near Ketchikan, Alaska.
Narantsetseg, Purevbaatar +1 more
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