Results 61 to 70 of about 4,466,202 (380)

Continuum Belief, Categorical Belief, and Depression Stigma: Correlational Evidence and Outcomes of an Online Intervention [PDF]

, 2019
Continuum belief interventions that erode boundaries between “normal” individuals and individuals with psychiatric problems may help to reduce psychiatric stigma, but a number of questions persist.
Thibodeau, Ryan
core   +1 more source

A Psychometric Properties Evaluation of the Italian Version of the Geriatric Depression Scale [PDF]

, 2018
Objective. The Geriatric Depression Scale (GDS) is an evaluation tool to diagnose older adult's depression. This questionnaire was defined by Yesavage and Brink in 1982; it was designed expressly for the older person and defines his/her degree of ...
Bruni, Valentina, Colucci, Mariele, De Santis, Rita, Galeoto, Giovanni, Sansoni, Julita, Scuccimarri, Michela, Tofani, Marco, Valente, Donatella   +7 more
core   +3 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Specific symptom change associated with ecological momentary assessments of intrusive trauma memories

NPP-Digital Psychiatry and Neuroscience
As the global prevalence of exposure to traumatic events rises, there is a growing need for accessible and scalable treatments for trauma-related disorders like posttraumatic stress disorder (PTSD).
Yara Pollmann, Kevin J. Clancy, Quentin Devignes, Boyu Ren, Milissa L. Kaufman, Isabelle M. Rosso   +5 more
doaj   +1 more source

Exploring the relationship between tychoparthenogenesis and inbreeding depression in the Desert Locust, Schistocerca gregaria [PDF]

, 2017
Tychoparthenogenesis, a form of asexual reproduction in which a small proportion of unfertilized eggs can hatch spontaneously, could be an intermediate evolutionary link in the transition from sexual to parthenogenetic reproduction.
Blondin, Laurence, Chapuis, Elodie, Chapuis, Marie Pierre, Jourdan, Hélène, Little, Chelsea   +4 more
core   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

Development, reach, acceptability and associated clinical changes of a group intervention to improve caregiver‐adolescent relationships in the context of adolescent depression

JCPP Advances, 2023
Background Adolescents with depression often experience relationship problems with their caregivers, which predict poorer treatment outcomes. Personalising interventions by targeting factors associated with poor treatment outcomes may enhance the ...
Madison Aitken, Ameeta Sagar, Darren Courtney, Peter Szatmari   +3 more
doaj   +1 more source

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Latent class analysis of actigraphy within the depression early warning (DEW) longitudinal clinical youth cohort

Child and Adolescent Psychiatry and Mental Health
Background Wearable-generated data yield objective information on physical activity and sleep variables, which, are in turn, related to the phenomenology of depression.
Lydia Sequeira, Pantea Fadaiefard, Jovana Seat, Madison Aitken, John Strauss, Wei Wang, Peter Szatmari, Marco Battaglia   +7 more
doaj   +1 more source