Results 71 to 80 of about 4,438,444 (356)

Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression

Translational Psychiatry, 2021
Lithium, a mood stabilizer and common adjunctive treatment for refractory depression, shares overlapping mechanisms of action with ketamine and enhances the duration of ketamine’s antidepressant actions in rodent models at sub-therapeutic doses.
J. Blair Price, Clarissa G. Yates, Brooke A. Morath, Sam K. Van De Wakker, Nathanael J. Yates, Kim Butters, Mark A. Frye, Sean L. McGee, Susannah J. Tye   +8 more
doaj   +1 more source

The importance of both setting and intensity of physical activity in relation to non-clinical anxiety and depression [PDF]

, 2007
Physical activity is associated with good physical and mental health. Current recommendations suggest that people should achieve 30 minutes of moderate-intensity activity most days of the week to gain health benefits.
Bernaards C M, Biddle S JH, Biddle S JH, Camacho T C, Clark A, Cooper-Patrick L, Department of Health, Der G, Dong W, Dunn A, Dunn A L, Ecob R, Farmer M, Goldberg D P, Kearney J M, Kritz-Silverstein D, Lawlor D A, Lawlor D A, Macintyre S, Mobily K E, Moses J, Moti R W, Mutrie N, OPCS, Paffenbarger R S, Pate R R, Schnohr P, Seligman M EP, Snaith R P, Strawbridge W J, Thorsen L, US Department of Health and Human Services, Van Gool C H, Weyerer S, World Health Organisation   +34 more
core   +2 more sources

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma, Rhonda Mittenzwei, Heather Maioli, Amanda Kirkland, C. Dirk Keene, Ramon Diaz‐Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan   +9 more
wiley   +1 more source

Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder

European Journal of Psychotraumatology
Introduction: Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates plasticity in brain systems underlying arousal and memory and is associated with posttraumatic stress disorder (PTSD).
Steven J. Granger, Victor May, Sayamwong E. Hammack, Eylül Akman, Sydney A. Jobson, Elizabeth A. Olson, Cameron D. Pernia, Nikos P. Daskalakis, Caitlin Ravichandran, William A. Carlezon, Kerry J. Ressler, Scott L. Rauch, Isabelle M. Rosso   +12 more
doaj   +1 more source

Associations between body dissatisfaction and self-reported anxiety and depression in otherwise healthy men: a systematic review and meta-analysis [PDF]

, 2020
Introduction It is unknown whether male body dissatisfaction is related to anxiety and depression. This study investigates whether there is an association between body dissatisfaction and self-reported anxiety and/or depression in otherwise healthy adult
Abhyankar, Purva, Barnes, Mathew, Best, Catherine, Dimova, Elena   +3 more
core   +4 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Modulatory effects of ketamine on EEG source-based resting state connectivity in treatment resistant depression

Translational Psychiatry
Treatment-resistant depression (TRD) accounts for approximately 30% of major depressive disorder cases and has been characterized by altered functional connectivity within and between the Default Mode (DMN) and Frontoparietal networks (FPN). Ketamine can
Ty Lees, Jason N. Scott, Brian W. Boyle, Shiba M. Esfand, Samantha R. Linton, Courtney Miller, Mohan Li, Sarah E. Woronko, Rebecca Dunayev, Mario Bogdanov, Paula Bolton, Shuang Li, Robert C. Meisner, Diego A. Pizzagalli   +13 more
doaj   +1 more source

Development, reach, acceptability and associated clinical changes of a group intervention to improve caregiver‐adolescent relationships in the context of adolescent depression

JCPP Advances, 2023
Background Adolescents with depression often experience relationship problems with their caregivers, which predict poorer treatment outcomes. Personalising interventions by targeting factors associated with poor treatment outcomes may enhance the ...
Madison Aitken, Ameeta Sagar, Darren Courtney, Peter Szatmari   +3 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Trauma-related intrusive memories and anterior hippocampus structural covariance: an ecological momentary assessment study in posttraumatic stress disorder

Translational Psychiatry
Trauma-related intrusive memories (TR-IMs) are hallmark symptoms of posttraumatic stress disorder (PTSD), but their neural correlates remain partly unknown.
Quentin Devignes, Boyu Ren, Kevin J. Clancy, Kristin Howell, Yara Pollmann, Lucia Martinez-Sanchez, Courtney Beard, Poornima Kumar, Isabelle M. Rosso   +8 more
doaj   +1 more source