Results 131 to 140 of about 786,893 (341)

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Neurocognitive subgroups in major depressive disorder

, 2020
Background: Major depressive disorder (MDD) is commonly associated with neurocognitive dysfunction. However, there remains substantial heterogeneity between patients and inconsistent findings regarding the magnitude and prevalence of specific ...
Alonzo, A , Lisanby, SH, Loo, CK , Martin, DM , McClintock, SM, Nikolin, S , Wollny-Huttarsch, D   +6 more
core   +1 more source

Thalamocortical connectivity in major depressive disorder [PDF]

, 2017
Background: Major Depressive Disorder (MDD) is highly prevalent and potentially devastating, with widespread aberrations in brain activity. Thalamocortical networks are a potential candidate marker for psychopathology in MDD, but have not yet been ...
Brown, Elliot C., Clark, Darren L., Hassel, Stefanie, MacQueen, Glenda, Ramasubbu, Rajamannar   +4 more
core   +1 more source

Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta‐analysis

World Psychiatry, 2015
Metabolic syndrome (MetS) and its components are highly predictive of cardiovascular diseases. The primary aim of this systematic review and meta‐analysis was to assess the prevalence of MetS and its components in people with schizophrenia and related ...
D. Vancampfort, B. Stubbs, A. Mitchell, M. De Hert, M. Wampers, P. Ward, S. Rosenbaum, C. Correll   +7 more
semanticscholar   +1 more source

Interfacial Yield Stress Response in Synthetic Mucin Solutions

Advanced Materials Interfaces, EarlyView.
The solution rheology of novel synthetic mucins mimicking natural mucin domains is studied. Like many natural mucin solutions, apparent solid‐like rheology is seen. However, no bulk structural features are found to explain it. Interfacial rheology and robust modelling reveal that this arises from molecular associations at the air–water interface ...
Sumit Sunil Kumar, Travis Leadbetter, J. Brandon McClimon, Manuel A. Lema, Farhana M. Khan, Prashant K. Purohit, Adam B. Braunschweig, Robert W. Carpick   +7 more
wiley   +1 more source

Understanding the dynamics of support seeking in women with lived experience of non‐physical intimate partner violence (IPV) and the service responses—A qualitative study

Australian Journal of Social Issues, Volume 57, Issue 4, Page 861-879, December 2022., 2022
Abstract Non‐physical abuse is a form of intimate partner violence (IPV), which negatively impacts physical and mental well‐being. The study objectives were to understand the process of support seeking amongst women who experience non‐physical IPV. Interviews were conducted with women who have experience of non‐physical IPV and support workers.
Karishma Doolabh, Colleen Fisher, Melissa O'Donnell   +2 more
wiley   +1 more source

MFCC-based Recurrent Neural Network for Automatic Clinical Depression Recognition and Assessment from Speech [PDF]

arXiv, 2019
Clinical depression or Major Depressive Disorder (MDD) is a common and serious medical illness. In this paper, a deep recurrent neural network-based framework is presented to detect depression and to predict its severity level from speech. Low-level and high-level audio features are extracted from audio recordings to predict the 24 scores of the ...
arxiv  

Understanding mechanisms of genetic risk for adolescent internalizing and externalizing problems: The mediating role of parenting and personality [PDF]

, 2018
Genetic predispositions play an important role in the development of internalizing and externalizing behaviors. Understanding the mechanisms through which genetic risk unfolds to influence these developmental outcomes is critical for developing ...
Bucholz, Kathleen K, Dick, Danielle M, Edenberg, Howard J, I-Chun Kuo, Sally, Kramer, John R, Schuckit, Marc, Su, Jinni   +6 more
core   +1 more source

Biological and Mechanical Limitations for Chronic Fast‐Scan Cyclic Voltammetry Sensor Design

Advanced Materials Technologies, EarlyView.
Real‐time detection of neurochemicals has demonstrated value in the field of neuroscience. However, current methods have limitations for use in the chronic setting, which is often the ideal environment for research. This article discusses these limitations, as well as technologies that have been developed to overcome them, and provides recommendations ...
Mason L. Perillo, Bhavna Gupta, Akash Saxena, Alexandra P. Veltri, Wen Li, James R. Siegenthaler, Erin K. Purcell   +6 more
wiley   +1 more source

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, EarlyView.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source