Aim This study builds on the environmental risk analysis presented in the 2022 National Report on Medicines Use in Italy by the Italian Medicines Agency and aims to assess the environmental risk posed by medicines in Italy and its regions. Methods The analysis selected 90 medicines based on three criteria: high utilization, low predicted no effect ...
Valentina Giunchi+8 more
wiley +1 more source
Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård+7 more
wiley +1 more source
Assessment of minimum clinically important difference in symptoms and functionality of Japanese patients with major depressive disorder following inadequate response to antidepressants: a <i>post hoc</i> analysis of the long-term study of brexpiprazole augmentation therapy in Japanese patients with major depressive disorder. [PDF]
Hori H+4 more
europepmc +1 more source
Abstract With levels of mental health difficulties among young people rising and policymakers focusing on the state's role in promoting young people's wellbeing, educational institutions have become positioned on the front line as key sites to identify and implement wellbeing interventions.
Ceri Brown+3 more
wiley +1 more source
History of Suicide Prevention with Lithium Treatment. [PDF]
Tondo L, Baldessarini RJ.
europepmc +1 more source
Abstract Many newcomer children spend a ‘silent year’ in elementary school classrooms while they adjust to a new culture and language. This often delays inclusion in learning and forming friendships with peers. For refugee children with disabilities (RCDs) this phase may last for 3 years or more, impacting their mental health and sense of belonging ...
Susan Barber
wiley +1 more source
A Systematic Review and Meta-Analysis of the Association Between Childhood Maltreatment and Adult Depression. [PDF]
Watson CB+4 more
europepmc +1 more source
Neural electrodes for brain‐computer interface system: From rigid to soft
Here, we review the development trends of neural electrodes in BCI. This paper highlights the critical role of electrodes in BCI systems, analyzes the limitations of rigid electrodes, and introduces various flexible electrodes. Furthermore, we discuss application scenarios and prospects of BCI electrode technology, aiming to provide valuable references
Dan Yang+7 more
wiley +1 more source
Altered resting-state amplitudes of low-frequency fluctuations in offspring of parents with a diagnosis of bipolar disorder or major depressive disorder. [PDF]
Boisvert M, Dugré JR, Potvin S.
europepmc +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu+7 more
wiley +1 more source