Results 61 to 70 of about 522,565 (283)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

A retrospective analysis to estimate the healthcare resource utilization and cost associated with treatment-resistant depression in commercially insured US patients.

PLoS ONE, 2020
ObjectiveThe economic burden of commercially insured patients in the United States with treatment-resistant depression and patients with non-treatment-resistant major depressive disorder was compared using data from the Optum Clinformatics™ claims ...
Gang Li, Ling Zhang, Allitia DiBernardo, Grace Wang, John J Sheehan, Kwan Lee, Johan Reutfors, Qiaoyi Zhang   +7 more
doaj   +2 more sources

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Major depressive disorder, personality disorders and coping strategies are independent risk factors for lower quality of life in non-metastatic breast cancer patients. [PDF]

, 2015
International audienceObjective: To identify risk factors for lower quality of life (QOL) in non-metastatic breast cancer patients.Methods: Our study included 120 patients from the University Hospital Centers of Tours and Poitiers.
Aaronson, Al-Azri, Bakas, Bloom, Boureau, Brunault, Brunault, Burgess, Carver, Cousson-Gélie, Dolbeault, Duijsens, Elumelu, Enfoux, Fallowfield, Ferlay, Fillion, Fournier, Helms, Huang, Härtl, Härtl, Ivanauskienė, Janz, Kroenke, Lecrubier, Leplège, Melzack, Montazeri, Morrill, Naaman, Rachet, Reich, Ruo, Sheehan, Sundaresan, Wilson   +36 more
core   +4 more sources

Executive functions in major depressive disorder

Sri Lanka Journal of Psychiatry, 2018
BackgroundIt is reported that executive functions are impaired in a variety of neuropsychiatric syndromes, including depressive disorders. Studies on executive functions in depressive disorders are inconclusive.
K. Dhawan, C.Y. Sudarshan, S. Begum
doaj   +1 more source

Hypermethylation in the ZBTB20 gene is associated with major depressive disorder [PDF]

, 2014
Background: Although genetic variation is believed to contribute to an individual's susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology of the disease ...
Alexis Battle, Anjali Henders, David A Collier, Emma Dempster, Enda Byrne, Fei Gao, Hanlin Lu, Honglong Wu, Jonathan Mill, Jordana T Bell, Jun Wang, Kirsten J Ward, Lutz Krause, Matthew N Davies, Naomi R Wray, Nicholas G Martin, null null, Pei-Chein Tsai, Sara Mostafavi, Therese Murphy, Tim D Spector, Xiaowei Zhu, Yuan Liu   +22 more
core   +2 more sources

TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara, Naoki Kihara, Satoko Miyatake, Koji Fujita, Konoka Tachibana, Ryosuke Miyamoto, Hiroki Yamazaki, Yusuke Osaki, Nazere Keyoumu, Yuki Kuwano, Nobutoshi Morimoto, Suzuran Saito, Eriko Koshimizu, Yoichi Otomi, Kenji Ishibashi, Masafumi Harada, Naomichi Matsumoto, Hiroyuki Morino, Yuishin Izumi   +18 more
wiley   +1 more source

A Cross-Sectional Trait Versus State Biomarker Analysis of Inflammatory Cytokines and miRNAs in Patients with Major Depressive Disorder

Indian Journal of Psychological Medicine
Background: Inflammatory cytokines are associated with the pathophysiology of major depressive disorder (MDD). Nevertheless, whether they are trait or state biomarkers remains unclear.
Christopher Rockson, Chandrashekaran Girish, Harivenkatesh Natarajan, Vikas Menon   +3 more
doaj   +1 more source

Major Depressive Disorder: A General Overview [PDF]

SHS Web of Conferences
Major Depressive Disorder (MDD) has become a serious mental health problem with a lifetime prevalence of 15% to 20%. MDD is associated with significant morbidity, mortality, disability, and negative influence on patient's daily life This article is an ...
Wang Tianqi
doaj   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source