Results 51 to 60 of about 39,697 (260)

Proteasome system dysregulation and treatment resistance mechanisms in major depressive disorder [PDF]

Translational Psychiatry, 2015
AbstractSeveral studies have demonstrated that allelic variants related to inflammation and the immune system may increase the risk for major depressive disorder (MDD) and reduce patient responsiveness to antidepressant treatment. Proteasomes are fundamental complexes that contribute to the regulation of T-cell function.
MINELLI, Alessandra, MAGRI, Chiara, BARBON, Alessandro, Bonvicini, Cristian, Segala, Matilde, CONGIU, Chiara, Bignotti, Stefano, MILANESI, Elena, Trabucchi, Luigi, CATTANE, Nadia, Bortolomasi, Marco, GENNARELLI, Massimo   +11 more
openaire   +2 more sources

Weaving Intelligence: Thermally Drawn Multimaterial Fibers Toward AI‐Enabled Smart Textiles

Advanced Materials, EarlyView.
Thermally drawn multimaterial fibers are rapidly advancing as intelligent structural units for next‐generation smart textiles. Integrating multimaterial architectures with neuromorphic and spiking‐neural‐network principles enables fabrics that can sense, compute, and adapt autonomously.
Vuong Dinh Trung, Jiaxiang Yi, Hieu Nguyen‐Duc, Tien Nu Hoang Lo, Weili Zhao, Chaoqun Dong, Fabien Sorin, Baris Caglar, Lei Wei, Tung Nguyen‐Dang   +9 more
wiley   +1 more source

Designable van der Waals Crystal for Artificial Neuronal Cell Mimicking

Advanced Materials, EarlyView.
Designable van der Waals crystal has been demonstrated for device‐scale neuronal cell mimicking. The structural similarity between ion‐channel in biological membranes and layered vdW lattices is realized with nano‐crystallization via Ar + H2S plasma sulfurization.
Jinhyoung Lee, Gunhyoung Kim, Dongho Lee, Seowoo Son, Hyunho Seok, Sihoon Son, Hyunbin Choi, Geonwook Kim, Geumji Back, Hyunkyu Kim, Chaerin Park, Junmin Ahn, Seongyun Je, Chaeyoung Im, Junil Cho, Magdalena Grzeszczyk, Seongho Kim, Eunseo Go, Hyunwoo Shim, Donghwan Choi, Muyoung Kim, Hyoeng‐U. Kim, Won‐Jun Jang, Taesung Kim   +23 more
wiley   +1 more source

Exploring Biological Risk Factors in Treatment-Resistant Depression

Psychiatry International
Treatment-resistant depression (TRD) affects 20–30% of patients with major depressive disorder and presents a significant clinical challenge due to its biological diversity.
Francisco Javier Lievanos-Ruiz, Bertha Fenton-Navarro   +1 more
doaj   +1 more source

Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

EJNMMI Research, 2020
Background Brain SPECT perfusion and PET metabolism have been, most often interchangeably, proposed to study the underlying pathological process in major depressive disorder (MDD).
Maud Tastevin, Laurent Boyer, Theo Korchia, Guillaume Fond, Christophe Lançon, Raphaëlle Richieri, Eric Guedj   +6 more
doaj   +1 more source

Augmentation of antidepressants with atypical antipsychotics for treatment‐resistant major depressive disorder [PDF]

Acta Psychiatrica Scandinavica, 2008
Objective: Atypical antipsychotics (AAPs) have been hypothesized to be beneficial in treatment‐resistant depression (TRD). This paper will review a biochemical rationale and will summarize the data regarding the effectiveness of AAPs in TRD.Method: Studies were identified using searches of Pubmed/Medline, EMBase and the Cochrane databases by cross ...
Richard C, Shelton, George I, Papakostas
openaire   +2 more sources

Engineering CO2 Reduction Pathways via Alloy‐Support Interactions in Li‐CO2 Batteries

Advanced Materials, EarlyView.
Alloy‐support interactions in RuCu/NC induce interfacial charge redistribution and shift d‐band centers, steering CO2 reduction from Li2CO3 to metastable Li2C2O4. This pathway engineering lowers the rate‐determining barrier and suppresses carbonate formation, enabling high discharge voltage (3.23 V) in Li‐CO2 batteries with reduced overpotential (0.50 ...
Liang Sun, Xindan Zhang, Guang Feng, Guoqiang Zhao, Bernt Johannessen, Guanjie Li, Shilin Zhang, Hongge Pan, Zaiping Guo   +8 more
wiley   +1 more source

Case series: Clinical response of ketamine infusion in patients with treatment-resistant depression

Telangana Journal of Psychiatry
Treatment-resistant depression (TRD) is one of the most debilitating conditions that does not respond to conventional pharmacotherapy. Ketamine is a recently used effective treatment option in depressive disorders with a novel mechanism of action. Still,
Pallavi Preetinanda, Srikrishna Nukala, Abhilash Garapati, Srinivas Singisetti, Niveditha Vasireddy, Vidya Sanapala, Ramya Spandana Tata   +6 more
doaj   +1 more source

Pharmacological Treatments for Patients with Treatment-Resistant Depression

Pharmaceuticals, 2020
Over a third of patients with major depressive disorder (MDD) do not have an adequate response to first-line antidepressant treatments, i.e., they have treatment-resistant depression (TRD).
Valerie L. Ruberto, Manish K. Jha, James W. Murrough   +2 more
doaj   +1 more source

Bias‐Field Free Single‐Frequency CW‐ODMR of Nitrogen‐Vacancy Centers in Diamond for the Detection of Transient Electrical Signals

Advanced Materials Interfaces, EarlyView.
Simplified quantum sensing technique for the detection of short electrical signals occurring in neuronal signaling or bioinspired technologies. We demonstrate a single frequency continuous‐wave optically detected magnetic resonance (CW‐ODMR) approach to sense signals that can be as short as 0.2 ms.
João Paulo Silva, Orlando D. Cunha, Pedro Magalhães, Filipe Camarneiro, Jana B. Nieder   +4 more
wiley   +1 more source