Results 51 to 60 of about 39,723 (259)

Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder [PDF]

Biological Psychiatry, 2014
While antidepressant treatment response appears to be partially heritable, no consistent genetic associations have been identified. Large, rare copy number variants (CNVs) play a role in other neuropsychiatric diseases, so we assessed their association with treatment-resistant depression (TRD).We analyzed data from two genome-wide association studies ...
Colm, O'Dushlaine, Stephan, Ripke, Douglas M, Ruderfer, Steven P, Hamilton, Maurizio, Fava, Dan V, Iosifescu, Isaac S, Kohane, Susanne E, Churchill, Victor M, Castro, Caitlin C, Clements, Sarah R, Blumenthal, Shawn N, Murphy, Jordan W, Smoller, Roy H, Perlis   +13 more
openaire   +2 more sources

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Case series: Clinical response of ketamine infusion in patients with treatment-resistant depression

Telangana Journal of Psychiatry
Treatment-resistant depression (TRD) is one of the most debilitating conditions that does not respond to conventional pharmacotherapy. Ketamine is a recently used effective treatment option in depressive disorders with a novel mechanism of action. Still,
Pallavi Preetinanda, Srikrishna Nukala, Abhilash Garapati, Srinivas Singisetti, Niveditha Vasireddy, Vidya Sanapala, Ramya Spandana Tata   +6 more
doaj   +1 more source

Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

EJNMMI Research, 2020
Background Brain SPECT perfusion and PET metabolism have been, most often interchangeably, proposed to study the underlying pathological process in major depressive disorder (MDD).
Maud Tastevin, Laurent Boyer, Theo Korchia, Guillaume Fond, Christophe Lançon, Raphaëlle Richieri, Eric Guedj   +6 more
doaj   +1 more source

Treatment-resistant depressive disorders: The when, how and what of augmentation therapy [PDF]

Australian & New Zealand Journal of Psychiatry, 2019
Darryl Bassett, Gordon Parker, Amber Hamilton, Grace Morris, Bernhard T Baune, Philip Boyce, Malcolm Hopwood, Roger Mulder, Richard Porter, Ajeet Singh, Tim Outhred, Zola Mannie, Pritha Das and Gin S ...
Darryl Bassett, Gordon Parker, Amber Hamilton, Grace Morris, Bernhard T Baune, Philip Boyce, Malcolm Hopwood, Roger Mulder, Richard Porter, Ajeet Singh, Tim Outhred, Zola Mannie, Pritha Das, Gin S Malhi   +13 more
openaire   +3 more sources

Escaping the Scaling Relationships in Oxygen Reduction Catalysis: Implications for PEM Fuel Cells

Advanced Materials, EarlyView.
Escaping the scaling relationships of the oxygen reduction reaction is vital for hydrogen fuel cells. This outlook examines how interfacial heterogeneity, spanning the subsurface lattice, chemisorption layer, and near‐interface solvation volume, mechanistically decouples intermediate binding energetics.
Muhammad Bilal Wazir, Lourdes F. Vega, Maryam Khaleel   +2 more
wiley   +1 more source

Exploring Biological Risk Factors in Treatment-Resistant Depression

Psychiatry International
Treatment-resistant depression (TRD) affects 20–30% of patients with major depressive disorder and presents a significant clinical challenge due to its biological diversity.
Francisco Javier Lievanos-Ruiz, Bertha Fenton-Navarro   +1 more
doaj   +1 more source

Pharmacological Treatments for Patients with Treatment-Resistant Depression

Pharmaceuticals, 2020
Over a third of patients with major depressive disorder (MDD) do not have an adequate response to first-line antidepressant treatments, i.e., they have treatment-resistant depression (TRD).
Valerie L. Ruberto, Manish K. Jha, James W. Murrough   +2 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Risperidone Augmentation in Antidepressant-Resistant Somatic Symptom Disorder

Psychiatry and Clinical Psychopharmacology
Chronic somatic symptoms are hallmarks of somatic symptom disorder (SSD), characterized by notable disruptions in the day to day lives of affected patients.
Eun Hyun Seo, Seung-Gon Kim, Hyung-Jun Yoon   +2 more
doaj   +1 more source