Results 181 to 190 of about 457,701 (285)

Long-Term Use of Benzodiazepines and Related Drugs in Persons With Major Depressive Disorder. [PDF]

Brain Behav
Laitinen H, Tiihonen M, Tanskanen A, Tiihonen J, Lieslehto J, Koponen M, Taipale H.   +6 more
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Utility of therapeutic drug monitoring in the treatment of major depressive disorder. [PDF]

Curr Opin Psychiatry
Schoretsanitis G, Paulzen M.
europepmc   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

The Role of Willpower in Major Depressive Disorder: An fMRI Study. [PDF]

Brain Behav
Yulug B, Uygur B, Sayman D, Cankaya S, Ayyıldız B, Ayyıldız S, Oktem EO, Akturk A, Ozsimsek A, Salar AB, Ozansoy M, Hanoglu L, Altay O, Velioglu HA, Mardinoglu A.   +14 more
europepmc   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Vortioxetine effectiveness in the treated major depressive disorder patients in Saudi Arabia. [PDF]

Ann Gen Psychiatry
Garatli A, Saad S, Alowesei R, Xavier F, Zeina M, Lofty W, Khalid M, Alharthi N, Talaat T, Asiri SA.   +9 more
europepmc   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

IMPACT OF COPING ON MICROSOCIAL RISK FACTORS FOR ADDICTIVE AND MIXED ANXIETY-DEPRESSIVE DISORDERS IN STUDENTS

, 2019
Ivan V. Voevodin
openalex   +2 more sources

ω-3 Fatty Acids in Pediatric Major Depressive Disorder: A Randomized Clinical Trial.

JAMA Netw Open
Berger G, Häberling I, Emery S, Albermann M, Baumgartner N, Nalani K, Strumberger M, Wöckel L, Erb S, Bachmann S, Müller-Knapp U, Contin-Waldvogel B, Yamini A, Rhiner B, Drechsler R, Held U, Reeve K, Heinz P, Pauli D, Schmeck K, Hersberger M, Walitza S, Omega-3 pMDD Study Group.   +22 more
europepmc   +1 more source