Results 191 to 200 of about 457,701 (285)

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder. [PDF]

Behav Brain Funct
Zhao X, Shang Y, Zhu W, Wareesawetsuwan N, Zhu L, Li C, Chen J, Bi Y.   +7 more
europepmc   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

Depressive Disorders [PDF]

, 1999
openaire   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Visualizing the Genetic Heterogeneity of Major Depressive Disorder using GDVIS

Thijssen AB, Milaneschi Y, Bartels M, Penninx BW, Pasman J, Verweij KJ, Peyrot WJ.   +6 more
europepmc   +1 more source

Identifying Physiological and Cognitive Indicators of Subthreshold Depression and Major Depressive Disorder Progression Risk. [PDF]

Neuropsychiatr Dis Treat
Shimizu A, Yokoyama S, Fermin ASR, Mitsuyama Y, Mizoi K, Yoshimoto J, Furukawa TA, Takagaki K, Okamoto Y, Okamoto Y, Okada G.   +10 more
europepmc   +1 more source

A Multifunctional Polar Amino Acid for Mixed Tin‐Lead Perovskites and All‐Perovskite Tandems

Advanced Science, EarlyView.
AsnCl improves film orientation and crystallinity, suppresses Sn4+ and PbI2 defects, and prolongs carrier lifetimes, enabling a 22.54% efficiency and enhanced stability in Sn–Pb perovskite solar cells. The AsnCl‐treated tandem device achieves a steady‐state PCE of 28.24%, underscoring the effectiveness of additive molecular engineering for high ...
Jin Zhou, Hongsen Cui, Chen Wang, Dexin Pu, Lishuai Huang, Shun Zhou, Guang Li, Qingxian Lin, Shining Zhang, Weiqing Chen, Guojia Fang, Weijun Ke, Weiwei Meng   +12 more
wiley   +1 more source

Features of cognitive dysfunction in patients with depressive disorder and cerebrovascular pathology

, 2017
Olga N. Prokhorova
openalex   +2 more sources

Impact of Depressive Disorder on Periodontal Status: A Comparative Study. [PDF]

Dent J (Basel)
Vasiliu BC, Mârțu MA, Oanță AC, Șufaru I, Păsărin L, Luchian AI, Solomon SM.   +6 more
europepmc   +1 more source