Results 211 to 220 of about 457,701 (285)

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

P33: From Depressive disorder with psychotic symptoms to Lewy Body Dementia (LBD)– The Importance of Differential Diagnosis in Psychogeriatrics: A Case Report [PDF]

Vinícius Boaventura Caio Lucena, João Emanuel Dias Tavares, Rodrigo Bainy Leal, Lucas G. Martins, Paulo Henrique Ferreira Bertolucci, Cleusa P. Ferri   +5 more
openalex   +1 more source

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications. [PDF]

Ann Med
Li Y, Lu Y, Lin X, Zhao L.
europepmc   +1 more source

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Lower ANXA3 Levels May Be Related to Major Depressive Disorder [PDF]

Mine Büşra Bozkürk, Kadir Özdel, Bilge Ozan Çiçek, Özkan Önder, Sinan Yildiz, Alpaslan Öztürk   +5 more
openalex   +1 more source

Novel and emerging physical treatments for major depressive disorder. [PDF]

Fundam Res
Cai Y, Wang D, Yang W, Jiang S, Qiang Z, Gao J, Shen L, Yao H.   +7 more
europepmc   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping

Huider F, milaneschi y, Pool R, Maciel B, Gordon S, Rietman ML, Kok A, Galesloot T, Mitchell B, Hart Lt, Rutters F, Blom M, Rhebergen D, Visser M, Brouwer I, Feskens E, Hartman C, Oldehinkel A, Bot M, de Geus E, Kiemeney L, Huisman M, Picavet HS, Verschuuren M, Martin N, Dolan C, Loo Hv, penninx b, Hottenga J, Boomsma D.   +29 more
europepmc   +1 more source

Polyphenol Consumption and Its Association with Physical and Mental Health in Adults with Major Depressive Disorder. [PDF]

Nutrients
Rog J, Pawlikowska P, Futyma-Jędrzejewska M, Wróbel-Knybel P, Maciejewski R, Kulczycka K, Karakula-Juchnowicz H.   +6 more
europepmc   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source