Results 41 to 50 of about 793,072 (247)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Field evaluation of a novel holographic single-image depth reconstruction sensor

Journal of the European Optical Society-Rapid Publications, 2023
A camera-based single-image sensor is presented, that is able to measure the distance of one or multiple object points (light emitters). The sensor consists of a camera, whose lens is upgraded with a diffractive optical element (DOE).
Hartlieb Simon, Schober Christian, Haist Tobias, Reichelt Stephan   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Focal plane model for flat refractive geometry

Journal of the European Optical Society-Rapid Publications, 2017
Background Flow visualization techniques such as uPIV and droplet imaging determine the measurement volume by the focal plane. Thus, an understanding of how the focal plane moves in reference to the camera is necessary when planar interfaces are present ...
Garrett W. Mann, Steven J. Eckels
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Extended Depth-of-Field of a Miniature Optical Endoscope Using Wavefront Coding

Applied Sciences, 2020
Endoscopic imaging is an indispensable tool for visual inspection of surfaces in hard-to-access places. The conventional optical endoscope only enables imaging the regions that lie close to the focal plane, and therefore improving the depth of field (DOF)
Lei Yang, Meng Chen, Jin Wang, Meng Zhu, Tong Yang, Shimin Zhu, Hongbo Xie   +6 more
doaj   +1 more source

Speckle structured illumination endoscopy with enhanced resolution at wide field of view and depth of field

Opto-Electronic Advances, 2023
Structured illumination microscopy (SIM) is one of the most widely applied wide field super resolution imaging techniques with high temporal resolution and low phototoxicity.
Elizabeth Abraham, Junxiao Zhou, Zhaowei Liu   +2 more
doaj   +1 more source