Results 41 to 50 of about 763,372 (283)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

4D Frequency Analysis of Computational Cameras for Depth of Field Extension [PDF]

, 2009
Depth of field (DOF), the range of scene depths that appear sharp in a photograph, poses a fundamental tradeoff in photography---wide apertures are important to reduce imaging noise, but they also increase defocus blur.
Anat Levin, Anat Levin, Paul Green, Samuel W. Hasinoff, William T. Freeman, William T. Freeman   +5 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Focal plane model for flat refractive geometry

Journal of the European Optical Society-Rapid Publications, 2017
Background Flow visualization techniques such as uPIV and droplet imaging determine the measurement volume by the focal plane. Thus, an understanding of how the focal plane moves in reference to the camera is necessary when planar interfaces are present ...
Garrett W. Mann, Steven J. Eckels
doaj   +1 more source

Field evaluation of a novel holographic single-image depth reconstruction sensor

Journal of the European Optical Society-Rapid Publications, 2023
A camera-based single-image sensor is presented, that is able to measure the distance of one or multiple object points (light emitters). The sensor consists of a camera, whose lens is upgraded with a diffractive optical element (DOE).
Hartlieb Simon, Schober Christian, Haist Tobias, Reichelt Stephan   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Coherent X-ray Diffractive Imaging; applications and limitations

, 2003
The inversion of a diffraction pattern offers aberration-free diffraction-limited 3D images without the resolution and depth-of-field limitations of lens-based tomographic systems, the only limitation being radiation damage.
A. Szoke, Beetz, Chapman, Elser, Fienup, H. He, H. N. Chapman, H. Padmore, He, Heel, Hegerl, Henke, J. C. H. Spence, M. R. Howells, McEwen, McGuire, Meyer-Ilse, Miao, Miao, Miao, Neutze, R. A. London, R. Rosen, S. Marchesini, S. P. Hau-Riege, Sayre, Solem, Solem, Spence, Szoke, Szöke, U. Weierstall, Weierstall, Zuo   +33 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Diffraction-limited plenoptic imaging with correlated light

, 2017
Traditional optical imaging faces an unavoidable trade-off between resolution and depth of field (DOF). To increase resolution, high numerical apertures (NA) are needed, but the associated large angular uncertainty results in a limited range of depths ...
D'Angelo, Milena, Di Lena, Francesco, Edrei, Eitan, Garuccio, Augusto, Mazzilli, Aldo, Pepe, Francesco V., Scarcelli, Giuliano   +6 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source