Results 81 to 90 of about 7,087,724 (289)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Single-cell mass spectrometry imaging of lipids in HeLa cells via tapping-mode scanning probe electrospray ionization

open access: yesCommunications Chemistry
The development of analytical technology that allows investigation of the diversity of cells that form biological tissues based on molecular information is important to elucidate the heterogeneity of cells and pathological mechanisms.
Yoichi Otsuka   +8 more
doaj   +1 more source

Does Position Affect Reduction? Comparison of the Effects of Three Different Positions on Reduction in Intertrochanteric Femur Fracture Nailing

open access: yesMedicina
Background and Objectives: Our study aimed to retrospectively examine the routine radiographs on the first postoperative day of osteosynthesis applications performed in the supine position with the help of a traction table, in the lateral decubitus ...
Nezir Okumuş, Ahmet Nadir Aydemir
doaj   +1 more source

Depth and Stanley depth of symbolic powers of cover ideals of graphs

open access: yes, 2017
Let $G$ be a graph with $n$ vertices and let $S=\mathbb{K}[x_1,\dots,x_n]$ be the polynomial ring in $n$ variables over a field $\mathbb{K}$. Assume that $J(G)$ is the cover ideal of $G$ and $J(G)^{(k)}$ is its $k$-th symbolic power.
Fakhari, S. A. Seyed
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Depth in a pathological case [PDF]

open access: yes, 2015
Let $I$ be a squarefree monomial ideal of a polynomial algebra over a field minimally generated by $f_1,...,f_r$ of degree $ d\geq 1$, and a set $E$ of monomials of degree $\geq d+1$. Let $J\subsetneq I$ be a squarefree monomial ideal generated in degree
Popescu, Dorin
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Improved measurement of depth perception [PDF]

open access: yes, 1972
Electromechanical system for Howard-Dolman device was developed.
Fitch, R. C., Miller, D. D.
core   +1 more source

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