Results 51 to 60 of about 320,019 (256)

Surface Roughness Prediction in Boring Turning of Ductile Cast Iron Using Response Surface Methodology and Tool Wear

RMUTL Engineering Journal, 2021
The research aims to study the surface roughness prediction in turning of ductile cast iron using response surface methodology with experiment design of Box-Behnken design. Factors used in the experiment include speed, feed rate, depth of cut, and corner
Julaluk Rodjananugoon, Surasit Rawangwong, Chatree Homkhiew   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Statistical analysis for machining force behaviour and surface morphology during turning of AISI 1040 steel under vegetable oil-in-water nanofluid lubrication

Materials Research Express
AISI 1040 medium-carbon steel offers a favourable combination of strength and toughness but presents notable machinability challenges for manufacturing industries. This study investigates metal turning operations on AISI 1040 using vegetable oil-in-water
Vishal Shenoy P, Vijay Kini M, Raghuvir Pai B, Srinivas Shenoy Heckadka, Raviraj Shetty, Supriya J P, Adithya Hegde   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Influence of turning cutting parameters on surface deformation of annealed AISI-1020 steel

Revista Facultad de Ingeniería Universidad de Antioquia
This paper presents a study on the influence of the cutting parameters (depth of cut, feed rate, and cutting speed) of turning with a carbide insert on the plastic deformation induced in annealed AISI-1020 steel.
Omar Zurita, Verónica Di Graci, Maria Capace   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Proposed Model to Minimize Machining Time by Chip Removal Under Structural Constraint Taking into Consideration Machine Power, Surface Finish, and Cutting Speed by Using Sorting Algorithms

Applied Sciences
This article proposes a model to estimate the optimal cutting speed and depth of cut used in the machining process by chip removal during the turning operation, considering the structural integrity of the workpiece to be machined.
Abraham Manilla-García, Néstor F. Guerrero-Rodriguez, Ivan Rivas-Cambero   +2 more
doaj   +1 more source