Results 81 to 90 of about 320,019 (256)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

INVESTIGATION OF THE EFFECT OF DEPTH OF CUT AND CUTTING SPEED ON CUTTING FORCES DURING FACE MILLING OF STEEL WITH A RECTANGULAR CUTTING INSERT

Cutting & Tools in Technological System, 2019
У процесах механічної обробки металу бажано досягнення досить високої швидкості видалення матеріалу. Швидкість видалення матеріалу може бути збільшена до бажаного значення шляхом збільшення значення швидкості подачі, а також шляхом збільшення швидкості різання або глибини різання.
Karkalos, Nikolaos E., Markopoulos, Angelos P., Makkai, Tamás, Kundrák, János   +3 more
openaire   +4 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Heat Transfer Enhancement of Laminar Nanofluids Flow in a Circular Tube Fitted with Parabolic-Cut Twisted Tape Inserts

The Scientific World Journal, 2014
Numerical investigation has been carried out on heat transfer and friction factor characteristics of copper-water nanofluid flow in a constant heat-fluxed tube with the existence of new configuration of vortex generator using Computational Fluid Dynamics
Sami D. Salman, Abdul Amir H. Kadhum, Mohd S. Takriff, Abu Bakar Mohamad   +3 more
doaj   +1 more source

THE IMPACT OF AREA AND SHAPE OF TOOL CUT ON CHAIN SAW PERFORMANCE

Rudarsko-geološko-naftni Zbornik, 2016
The cutting design of the chain saw is defined by the number, the arrangement and the geometry of the cutting tools. When using chisel cutting tools, the cross sectional area of the cut and the shape of the groove are determined by the width and depth of
Tomislav Korman, Trpimir Kujundžić, Hrvoje Lukačić, Milan Martinić   +3 more
doaj   +1 more source

Study on Rubbing-Cutting Transition Phenomena at the Depth of Cut Increase Gradually

Journal of the Japan Society of Precision Engineering, 1968
Rubbing-cutting transition phenomena are studied on the orthogonal cutting in which depth of cut increases gradually.Specimens of steels with various hardness are cut by two dimentional tools of SKH4 that have various roundness of cutting edge. On that occasion the thrust component of cutting force falls down suddenly when a pilled-up material on the ...
Akira YAMAMOTO, Simesu NAKAMURA
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Prediction of cutting depth in abrasive water jet machining of Ti-6AL-4V alloy using back propagation neural networks

Results in Engineering
The current study focusses on developing a back propagation neural network model for depth of cut during the abrasive water jet machining of a Ti-6AL-4V aluminum alloy.
Yakub Iqbal Mogul, Ibtisam Mogul, Jaimon Dennis Quadros, Ma Mohin, Abdul Aabid, Muneer Baig, Mohammad Abdul Malik   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source