Results 141 to 150 of about 94,977 (267)

[Requirements for the rational use of antibiotics based on antibiotic stewardship]. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
de With K, Draenert R, Nurjadi D, Hagel S, Trost U, Fahrenkrog-Petersen J, Kern WV, Kramme E.   +7 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

[Autism spectrum disorders-Transition from adolescence into adulthood]. [PDF]

Nervenarzt
Freitag CM, Tebartz van Elst L.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A neuropsychological perspective on sensory hypersensitivity after acquired brain injury. [PDF]

Brain Commun
Heijman JO, Marzolla MC, Thielen H, Spielmann K, Königs M, Gillebert CR, van Heugten CM, van der Stoep N, Huenges Wajer IMC.   +8 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Jenseits der Integration

, 2021
Hess, Sabine, Moser, Johannes, Hess, Sabine, Binder, Jana, Moser, Johannes   +4 more
openaire   +1 more source

2D Nanomaterials Toward Function-Ready Superlubricity in Advanced Microsystems. [PDF]

Adv Mater
Geng Y, Yang J, Yang Y.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Breakthrough in 2D ultrahigh-<i>κ</i> dielectrics by paraelectric phase engineering in van der Waals crystal. [PDF]

Natl Sci Rev
Wu Q, Peng H.
europepmc   +1 more source