Results 111 to 120 of about 216,687 (267)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Vertikale Integration der Produktion
, 2010 enDie IT von Produktionsanlagen ist in vielen Unternehmen isoliert, stark funktionsorientiert und weist zahlreiche Schnittstellen und Medienbrüche auf. Der zunehmende globale Wettbewerbsdruck erfordert, dass ein Produktionsbetrieb die Geschäftsprozesse ...
Rybczynski, Wolfgang, Oefner, Andreas
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Integration of DER & RES in Power System and Distribution Network Design
The European Integrated Project EU-DEEP, which deals with the integration of Distributed Energy Resources in the transmission and distribution system, proposes technical, operational and regulatory analyses, developed in a coordinated way, as the best ...
Deuse, J. +3 more
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Integration und Bewertung der Ergebnisse
, 1980 Eine Beantwortung der eingangs gestellten Untersuchungsfragen (s. o. Kap. 1.) erfordert eine Integration der Ergebnisse aus den drei empirischen Teiluntersuchungen.
Groeben, Norbert
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A trade-off between enlargement and integration? An analysis of trust between EU nationalities [PDF]
This paper analyses the impact enlargements have had on the integration of the European Union (EU). For this purpose, integration was conceptualised as the sense of community across national boundaries and measured as interpersonal trust between EU ...
Delhey, Jan
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Helden in der Schule : Akten der Tagung Kloster Banz 2014
, 2017 Ausgehend von der Feststellung, dass die Integration mittelalterlicher Texte im Deutschunterricht in der Schulpraxis weitgehend ein Desiderat darstellt, präsentierten Beitragende aus Schule und Wissenschaft bei der Tagung „Helden in der Schule“ im ...
Elste, Nico +27 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source