Results 71 to 80 of about 94,977 (267)

Mare nostrum = nostrum sepulcrum? Das Mittelmeer als Massengrab für Migranten und das Dilemma europäischer Flüchtlingspolitik Zur aktuellen Kontroverse über die neuen „Boatpeople“

Germanistica Euromediterrae
Die von einer Jury deutscher Linguisten ausgewählten „Unwörter des Jahres“ (wie Pushback, Asyltourismus, Anti-Abschiebeindustrie, Überfremdung) beziehen sich nicht selten auf die in Deutschland (aber nicht nur dort) anhaltenden Kontroversen über ...
Ernest W.B. Hess-Lüttich
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Concepts for cultural integration after M&A

Business: Theory and Practice, 2011
When integrating corporate cultures after Mergers & Acquisitions (M&A) the conceptual approach is of central importance. This integrated approach should be selected before the actual integration takes place.
Andreas Palm
doaj  

Stand und Perspektive von ORCID in Deutschland

Bibliothek
Mit dem ORCID-Standard wurde ein System der persistenten Identifikatoren für Forschende geschaffen. Der Förderung von ORCID in Deutschland widmete sich von 2016 bis 2022 das von der Deutschen Forschungsgemeinschaft (DFG) geförderte Projekt ORCID DE. Dank
Pampel Heinz, Schrader Antonia C., Vierkant Paul, Dreyer Britta, Glagla-Dietz Stephanie, Hartmann Sarah, Schirrwagen Jochen, Summann Friedrich   +7 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Konzeption und Evaluation eines fallbasierten Trainingssystems im universitätsweiten Einsatz (CaseTrain)

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2009
Basierend auf umfangreichen Erfahrungen mit fallbasierten Trainingssystemen in der Medizin werden Anforderungen, Umsetzung und eine universitätsweite Evaluation des fachübergreifenden Players und Autorensystem für fallbasiertes Training CaseTrain ...
Hörnlein, Alexander, Ifland, Marianus, Klügl, Peter, Puppe, Frank   +3 more
doaj  

Sprachunterricht als Transformationsraum

DiSlaw
Trotz der zunehmenden Wichtigkeit der Bildung für nachhaltige Entwicklung (BNE) in bildungspolitischen Kontexten bleibt ihre Integration in Sprachkurse auf Hochschulniveau begrenzt.
Natalia Schwarzl
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source