Results 71 to 80 of about 97,672 (267)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Concepts for cultural integration after M&A
Business: Theory and Practice, 2011 When integrating corporate cultures after Mergers & Acquisitions (M&A) the conceptual approach is of central importance. This integrated approach should be selected before the actual integration takes place.
Andreas Palm
doaj
Stand und Perspektive von ORCID in Deutschland
BibliothekMit dem ORCID-Standard wurde ein System der persistenten Identifikatoren für Forschende geschaffen. Der Förderung von ORCID in Deutschland widmete sich von 2016 bis 2022 das von der Deutschen Forschungsgemeinschaft (DFG) geförderte Projekt ORCID DE. Dank
Pampel Heinz +7 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
GMS Medizinische Informatik, Biometrie und Epidemiologie, 2009 Basierend auf umfangreichen Erfahrungen mit fallbasierten Trainingssystemen in der Medizin werden Anforderungen, Umsetzung und eine universitätsweite Evaluation des fachübergreifenden Players und Autorensystem für fallbasiertes Training CaseTrain ...
Hörnlein, Alexander +3 more
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Sprachunterricht als Transformationsraum
DiSlawTrotz der zunehmenden Wichtigkeit der Bildung für nachhaltige Entwicklung (BNE) in bildungspolitischen Kontexten bleibt ihre Integration in Sprachkurse auf Hochschulniveau begrenzt.
Natalia Schwarzl
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source