KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
[Evidence generation and methodological consultation by the project "EVAluation research based on data from routine clinical care 4 the Medical Informatics Initiative" (EVA4MII)]. [PDF]
Pfaffenlehner M +10 more
europepmc +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Editorial: Transforming chronic disease treatment with AI and big data. [PDF]
Xing X, Sun Z, Yang K, Wei S.
europepmc +1 more source
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Digital innovations and health information systems: Lessons learned from implementing ALMANACH in Nigeria. [PDF]
Bernasconi A +4 more
europepmc +1 more source
Editorial: Innovations in pharmacogenomics: embracing diversity and clinical application. [PDF]
Van der Lee M +4 more
europepmc +1 more source
Artificial intelligence in head and neck cancer rehabilitation services: current state and future perspectives. [PDF]
van Koevorden JW +2 more
europepmc +1 more source
Educational strategies for integrating gender perspectives in health professions training: a systematic review to advance diversity, equity, and inclusion. [PDF]
López K +3 more
europepmc +1 more source

