Results 61 to 70 of about 101,704 (267)

Internationaler Stellenwert der Heilpädagogik in der Lehrergrundausbildung

Beiträge zur Lehrerinnen- und Lehrerbildung, 1995
Angesichts der zunehmend propagierten und realisierten Integration behinderter Kinder und Jugendlicher ins Regelschulsystem wird der Frage nachgegangen, ob international gesehen dieser Tendenzwende bei der Grundausbildung der Lehrpersonen Rechnung ...
Alois Bürli
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

DMP Asthma-Positionspapier mit Handlungsempfehlungen

Monitor Versorgungsforschung
Einleitung: Das Disease-Management-Programm (DMP) Asthma bronchiale weist relevante Abweichungen von aktuellen nationalen und internationalen Leitlinien auf.
Elke Alsdorf, Dr. med. Jens C. Becker, Dr. med. Stefanie Bendig, Prof. Dr. med. habil. Marek Lommatzsch, Dr. med. Sylvia Schnitzer, Dr. rer. nat. Tom Trenkmann   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Libre circulation, capacités d’intégration et plurilinguisme: une impossible convergence?

Babylonia
Die Kompetenzen in den Landessprachen werden in der Schweiz in erster Linie über den Fremdsprachenunterricht in der obligatorischen Schule vermittelt.
Till Burckhardt
doaj  

Eltern- und Kinderfreundschaften in Ost- und Westberlin

Journal of Family Research, 1997
Das soziale Netzwerk von Eltern kann eine Bereicherung der kindlichen Sozialwelt darstellen. Erwartet wird ein Effekt der elterlichen Integration in einen Freundeskreis auf die kindliche Integration in Gleichaltrigenbeziehungen und auf die Entwicklung ...
Harald Uhlendorff
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source