Results 51 to 60 of about 101,704 (267)
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Der zweisprachige Unterricht (in Europa oft als CLIL bezeichnet) hat sich in der Schweiz insbesondere in der Sekundarstufe II gut etabliert. In der obligatorischen Schule hingegen ist es noch nicht so weit, auch wenn sich mehrere interessante Projekte ...
Laurent Gajo +3 more
doaj
Offen, verantwortlich und verantwortlich offen
Sowohl Open Science als auch Responsible Research and Innovation (RRI) zielen auf tiefgreifende Transformationen im Innovationssystem durch eine stärkere Öffnung von Forschung und Entwicklung für gesellschaftliche Akteure.
Johann Jakob Häußermann +1 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Raumwirtschaftliche Aspekte der Kohäsionspolitik vor dem Hintergrund neuer Außenhandelstheorien
Die Diskussion um die Kohäsionspolitik der Europäischen Union beschränkt sich weitgehend auf die Frage nach der Höhe verteilungspolitisch relevanter Transfers in ärmere Beitrittsländer.
Gerhard Fisch
doaj
Verschiedenste Forschungsprojekte haben gezeigt, dass die Integration von Schülerinnen und Schülern mit besonderem Bildungsbedarf in eine Regeklasse mehr Vorteile bringt als deren Separation.
Pierre-André Doudin +2 more
doaj +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source

