Results 51 to 60 of about 97,672 (267)

IKT bei Freiburger Lehrpersonen: Informatikkenntnisse und Integrationsstufe

open access: yesBeiträge zur Lehrerinnen- und Lehrerbildung, 2012
In diesem Beitrag werden die Ergebnisse einer Studie der Pädagogischen Hochschule Freiburg vorgestellt. Untersucht wurden die Informatikkenntnisse sowie die Verwendung von IKT im Unterrichtskontext bei Freiburger Lehrpersonen vom Kindergarten bis zur ...
Jérôme A. Schumacher   +1 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Künstliche Intelligenz (KI) in der Bildung - Ein KInderspiel?

open access: yesMedienimpulse
Diese Arbeit widmet sich der Integration und den Auswirkungen von generativer künstlicher Intelligenz (KI) im Bildungswesen. Es werden eine Vielzahl von praktischen Anwendungsfällen vorgestellt, in denen KI den Unterricht unterstützen kann – von der ...
Barbara Sabitzer   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Integration der Gesellschaft in die Zielformulierung der Regionen

open access: yesRaumforschung und Raumordnung, 2002
More importance must be attached to social participation if the role of regional planning processes is to be strengthened and implementation deficits redressed. Participation in regional planning can be practicable, as is shown by examples such as
Thomas Thrun
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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