Results 141 to 150 of about 20,039,291 (337)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Auslaender in der Grossstadt Zum Problem der kommunalen Integration der tuerkischen Bevoelkerung

open access: yes, 1984
Der Autor untersucht am konkreten Fall der Stadt Augsburg die Integrationsproblematik auslaendischer Bevoelkerungsgruppen am Beispiel der tuerkischen Bevoelkerung.
Universitaet Augsburg, Mathematisch-Naturwissenschaftliche Fakultaet, Lehrstuhl fuer Sozial- und Wirtschaftsgeographie, Augsburg (Germany)   +2 more
core  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Vetmed: das Magazin der Veterinärmedizinischen Universität Wien und der Gesellschaft der Freunde der Veterinärmedizinischen Universität Wien 1/2024

open access: yes
Das Universitätsmagazin berichtet über die vielfältigen Aktivitäten der Universität in Forschung, Studium und Universitätskliniken, informiert über Tiergesundheit, Tierhaltung und Tierschutz sowie Lebensmittelsicherheit und beschäftigt sich mit Fragen ...
Gesellschaft der Freunde der Veterinärmedizinischen Universität Wien   +1 more
core   +1 more source

Zuwanderung nach Österreich. Integrationspolitische Herausforderungen

open access: yesÖsterreichisches Religionspädagogisches Forum, 2016
ENGLISH: Since the early 1960ies, Austria has become an immigration country against its will. In the beginning, the migration of Guestworkerswas a flexible supplement of the national labour market.
Heinz Faßmann
doaj  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Herausforderungen muslimischer Integration. Darstellung und Kommentar der Studie ‚Why Muslim Integration Fails in Christian- Heritage Societies‘

open access: yesÖsterreichisches Religionspädagogisches Forum, 2016
ENGLISH: The integration of Muslim migrants has become a major issue in public debates in various European countries, among them Austria. The debates comprise political, social, and also pedagogical questions.
Christian Feichtinger
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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