Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
[Consensus paper for the standardized laboratory diagnostics of chronic kidney disease (CKD) in the context of cardiovascular-renal-metabolic health (ÖGLMKC, ÖQUASTA, ÖGN) : Consensus paper of the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC), the Austrian Society for Quality Assurance and Standardization of Medical Diagnostic Examinations (ÖQUASTA), and the Austrian Society for Nephrology (ÖGN)]. [PDF]
Wien Klin WochenschrEller K +10 more
europepmc +1 more source
The linguistic and educational integration of children and adolescents from migrant backgrounds
BabyloniaDie Integration von Migranten und Migrantinnen in den Aufnahmeländern, ist für den sozialen Zusammenhalt von fundamentaler Bedeutung und daher ein zentrales Anliegen des Europarats.
David Little
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Timely Integration of specialist palliative care into oncology care for patients receiving radiotherapy for bone metastases: A study procotol for the TIPZO-RT Randomized Controlled Trial. [PDF]
PLoS Onevan Oss A +9 more
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
A socio-technical framework for cyber-resilience in hybrid oil-renewable energy grids. [PDF]
Cybersecur (Singap)Anderson B, Hossain G.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
[Complex family interventions in intensive care units: state of knowledge and future directions]. [PDF]
Med Klin Intensivmed NotfmedVerweij L, Sutter S, Kohler M, Naef R.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source