Results 61 to 70 of about 94,977 (267)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Eltern- und Kinderfreundschaften in Ost- und Westberlin

Journal of Family Research, 1997
Das soziale Netzwerk von Eltern kann eine Bereicherung der kindlichen Sozialwelt darstellen. Erwartet wird ein Effekt der elterlichen Integration in einen Freundeskreis auf die kindliche Integration in Gleichaltrigenbeziehungen und auf die Entwicklung ...
Harald Uhlendorff
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mediatisierte Kommunikation in Mediengesellschaften

MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung, 2001
Mediatisierte Kommunikation als Begriff und Konzept steht hier in der theoretischen Tradition, die Diagnose einer zunehmenden Heterogenisierung moderner Gesellschaften mit der Suche nach einem kompensatorischen Pendant, der sozialen (Re-)Integration ...
Uwe Sander
doaj  

Die Rolle der Lehrenden im KI-gestützten Lehr-Lernprozess

Zeitschrift für Hochschulentwicklung
Dieser Beitrag untersucht die wahrgenommenen Auswirkungen von Künstlicher Intelligenz (KI) auf die Lehrenden-Studierenden-Beziehung in der Hochschullehre anhand von 16 Interviews mit Lehrenden.
Tanja Jadin, Ursula Rami, Stephanie Schwarz, Isabella Buchinger   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Libre circulation, capacités d’intégration et plurilinguisme: une impossible convergence?

Babylonia
Die Kompetenzen in den Landessprachen werden in der Schweiz in erster Linie über den Fremdsprachenunterricht in der obligatorischen Schule vermittelt.
Till Burckhardt
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source