Results 31 to 40 of about 216,687 (267)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
"Climate Proofing" - Ein Framework zur Integration der Klimawandelanpassung in die Raumplanung
, 2021 Die letzten Jahre haben die „Klimakrise“ in das gemeinschaftliche Bewusstsein gerückt. In der Bundes-, Landes- und Kommunalpolitik sowie der Verwaltung werden Maßnahmen zum Klimaschutz und der Klimawandelanpassung breit diskutiert und entwickelt.
Weichselbaumer, Roswitha +3 more
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IEEE AccessWith the growing need for transitioning to clean energy, increasing the share of renewable energy sources has become a global priority. The integration of distributed energy resources (DERs), such as photovoltaic (PV) and wind turbine (WT) systems, is ...
Jun-Hyuk Nam +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Globalization, Regional Integration and the EU: Pleadings for a Broader Perspective. ZEI Discussion Papers C162, 2006 [PDF]
, 2006 [From the Introduction]. Whether we agree to more positive or rather skeptical positions on globalization, it is assumable that globalization and regional integration are related issues.
Janowski, Cordula.
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
e-Health technologies for adult hearing screening
Audiology Research, 2011 The development of hearing diagnosis methods and hearing screening methods are not isolated phenomena: they are intimately related to changes in the cultural background and to advances in fields of medicine and engineering. In the recent years, there has
S. Stenfelt +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Zum Potenzial der Integration von Migrantinnen in den Sport durch interkulturelle Vereine [PDF]
, 2015 Einleitung Im deutschsprachigen Raum besteht ein hoher Anteil an sportlich inaktiven und in Sportvereinen unterrepräsentierten Migrantinnen (Burrmann et al., 2015; Lamprecht et al., 2014). Migrantinnen ist der Zugang zu Sportaktivitäten häufig erschwert
Adler Zwahlen, Jenny +1 more
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