Results 11 to 20 of about 13,781 (277)

Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation

Marine Drugs, 2023
Natural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of known ...
Susana P. Gaudêncio, Engin Bayram, Lada Lukić Bilela, Mercedes Cueto, Ana R. Díaz-Marrero, Berat Z. Haznedaroglu, Carlos Jimenez, Manolis Mandalakis, Florbela Pereira, Fernando Reyes, Deniz Tasdemir   +10 more
doaj   +2 more sources

Dereplication of microbial metabolites through database search of mass spectra

Nature Communications, 2018
New natural products can be identified via mass spectrometry by excluding all known ones from the analysis, a process called dereplication. Here, the authors extend a previously published dereplication algorithm to different classes of secondary ...
Hosein Mohimani, Alexey Gurevich, Alexander Shlemov, Alla Mikheenko, Anton Korobeynikov, Liu Cao, Egor Shcherbin, Louis-Felix Nothias, Pieter C. Dorrestein, Pavel A. Pevzner   +9 more
doaj   +2 more sources

Planar chromatographic super-hyphenations for rapid dereplication

Phytochemistry Reviews, 2022
Abstract Analytical chemistry offers important tools that provide insight and step-by-step understanding. However, natural samples containing many thousands of different compounds are subject to natural variance which makes it complex for artificial intelligence and human understanding.
Morlock, Gertrud E., Justus Liebig University Giessen   +1 more
openaire   +3 more sources

Introducing SPeDE: High-Throughput Dereplication and Accurate Determination of Microbial Diversity from Matrix-Assisted Laser Desorption–Ionization Time of Flight Mass Spectrometry Data [PDF]

mSystems, 2019
The isolation of microorganisms from microbial community samples often yields a large number of conspecific isolates. Increasing the diversity covered by an isolate collection entails the implementation of methods and protocols to minimize the number of ...
Charles Dumolin, Maarten Aerts, Bart Verheyde, Simon Schellaert, Tim Vandamme, Felix Van der Jeugt, Evelien De Canck, Margo Cnockaert, Anneleen D. Wieme, Ilse Cleenwerck, Jindrich Peiren, Peter Dawyndt, Peter Vandamme, Aurélien Carlier   +13 more
doaj   +4 more sources

Targeted Dereplication of H. patulum and H. hookeranium Extracts: Establishing MS/MS Fingerprints for the Identification of Polycyclic Polyprenylated Acylphloroglucinols [PDF]

Molecules
In this study, we combined automated annotation tools with targeted dereplication based on MS/MS fragmentation pathway studies to identify polycyclic polyprenylated acylphloroglucinols (PPAPs) in Hypericum species, using H. patulum and H.
Annabelle Dugay, Florence Souquet, David Hozain, Gilles Alex Pakora, Didier Buisson, Séverine Amand, Marie-Christine Lallemand, Raimundo Gonçalves de Oliveira Junior   +7 more
doaj   +2 more sources

Dereplication of Bioactive Agave Saponin Fractions: The Hidden Saponins

Journal of Agricultural and Food Chemistry
The good phytotoxicity and selectivity against weeds versus tomato or cress make saponin-rich fractions from Agave macroacantha, A. colorata, A. parryi, and A. parrasana attractive candidates as bioherbicides. The saponin contents have only previously been reported for A. macroacantha, and as a consequence, simultaneous dereplication has been performed
Ana M. Simonet, Alexandra G. Durán, Francisco A. Macías   +2 more
openaire   +4 more sources

Endophytic Fungi of Calea pinnatifida (Asteraceae): Dereplication of Crude Extracts, Antimicrobial Properties, and Identification of New Tetronic Acid Derivative Produced by Hypomontagnella barbarensis [PDF]

Journal of Fungi
Endophytic fungi are increasingly being recognized for their diverse metabolites that may exhibit antimicrobial properties. In our study, we isolated seven endophytic fungal strains from Calea pinnatifida, which were identified as Hypomontagnella ...
Bianca Barna, Lhaís Araújo Caldas, Jackson Monteiro, Augusto Leonardo dos Santos, Renata Castiglioni Pascon, Marcelo Afonso Vallim, Marcelo José Pena Ferreira, Sarah Santos Gonçalves, Glaucia Queiroz dos Santos, Anderson Messias Rodrigues, Jamile Ambrósio de Carvalho, Suzan Pantaroto de Vasconcellos, Patricia Sartorelli   +12 more
doaj   +2 more sources

Metabolomics and dereplication study of the British bluebell [PDF]

, 2015
Using Metabolomics as a tool to enhance natural products drug discovery.
Tawfike, Ahmed, Raheem, Dotsha, Thoss, Vera, Edrada-Ebel, Ruangelie   +3 more
openaire   +3 more sources

UHPLC-ESI-QTOF-MS/MS-Based Molecular Networking Guided Isolation and Dereplication of Antibacterial and Antifungal Constituents of Ventilago denticulata

Antibiotics, 2020
Ventilago denticulata is an herbal medicine for the treatment of wound infection; therefore this plant may rich in antibacterial agents. UHPLC-ESI-QTOF-MS/MS-Based molecular networking guided isolation and dereplication led to the identification of ...
Muhaiminatul Azizah, Patcharee Pripdeevech, Tawatchai Thongkongkaew, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop   +5 more
doaj   +2 more sources

Blini: lightweight nucleotide sequence search and dereplication

Blini is a tool for quick lookup of nucleotide sequences in databases, and for quick dereplication of sequence collections. It is meant to help clean and characterize large collections of assembled contigs or long sequences that would otherwise be too big to search with online tools, or too demanding for a local machine to process.
Lavon, Amit
openalex   +3 more sources