Results 241 to 250 of about 13,781 (277)

13C NMR-based dereplication using MixONat software to decipher potent anti-cholinesterase compounds in Mesua lepidota bark.

Bioorganic chemistry (Print), 2023
A bio-assay guided fractionation strategy based on cholinesterase assay combined with 13C NMR-based dereplication was used to identify active metabolites from the bark of Mesua lepidota.
Sow Tein Leong, Sook Yee Liew, K. Khaw, Hazlina Ahmad Hassali, P. Richomme, S. Derbré, V. Lee, Ruzanna Yahya, K. Awang   +8 more
semanticscholar   +1 more source

Mass spectrometry as a tool for the dereplication of specialised metabolites from Pterocaulon angustifolium DC

Natural Product Research, 2023
Pterocaulon genus comprises 26 species, half of them have been phytochemical investigations regarding the chemical composition, and coumarins have been considered the chemotaxonomic markers in the genus.
B. P. Moreno, F. A. Pereira, Aline A R Andrade, M. Cabral, Alana C Battistella, T. Tiuman, M. Foglio, A. L. T. G. Ruiz, M. R. B. do Carmo, M. Sarragiotto, D. Baldoqui   +10 more
semanticscholar   +1 more source

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Journal of Visualized Experiments, 2019
One of the main challenges in the search for new antibiotics from natural product extracts is the re-discovery of common compounds. To address this challenge, dereplication, which is the process of identifying known compounds, is performed on samples of interest.
Haley L, Zubyk, Georgina, Cox, Gerard D, Wright   +2 more
openaire   +2 more sources

Dereplication of natural cytotoxic products from Helichrysum oligocephalum using ultra‐performance liquid chromatography–quadrupole time of flight‐mass spectrometry

Separation Science Plus, 2023
In an ongoing project on the Iranian Helichrysum Mill. species (Asteraceae), the phytochemical profiles of the extracts obtained from the flower and leaves of Helichrysum oligocephalum were investigated utilizing ultra‐performance liquid chromatography ...
Faezeh Zanganeh, Z. Tayarani-Najaran, K. Nesměrák, M. Štícha, S. Emami, M. Akaberi   +5 more
semanticscholar   +1 more source

LCMS-DNP based dereplication of Araucaria cunninghamii Mudie gum-resin: identification of new cytotoxic labdane diterpene

Natural Product Research, 2022
As a part of natural defense, plants initiate the secretion of gum containing numerous pharmacologically active essential metabolites. A fraction of such gum-resin from Araucaria cunninghamii Mudie, when screened against human cancer cell lines, was ...
Bharat Sahu, Nivedita Bhardwaj, Essha Chatterjee, Biswajit Dey, Nancy Tripathi, Bharat Goel, M. Kushwaha, B. Kumar, Bikarma Singh, S. Guru, Shreyans K. Jain   +10 more
semanticscholar   +1 more source

Metabolomics and Dereplication Strategies in Natural Products

2013
Metabolomic methods can be utilized to screen diverse biological sources of potentially novel and sustainable sources of antibiotics and pharmacologically-active drugs. Dereplication studies by high resolution Fourier transform mass spectrometry coupled to liquid chromatography (LC-HRFTMS) and nuclear magnetic resonance (NMR) spectroscopy can establish
Tawfike, Ahmed Fares, Viegelmann, Christina, Edrada-Ebel, Ruangelie   +2 more
openaire   +3 more sources

Dereplication of Phorbol Bioactives: Lyngbya majuscula and Croton cuneatus

Journal of Natural Products, 1990
Lyngbya majuscula and Croton cuneatus were used as prototypes for the dereplication of phorbol ester receptor binding activity using a combination of hplc-uv and online phorbol dibutyrate (PDBu) receptor binding and batch fractionation over either Si gel or diolbonded Si gel. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a
J A, Beutler, A B, Alvarado, D E, Schaufelberger, P, Andrews, T G, McCloud   +4 more
openaire   +2 more sources

Streptomycetes as a promising source of antimicrobial compounds: A GC-MS-based dereplication study.

Microbial Pathogenesis
The extensive microbial resistance to existing antimicrobial medicines presents a significant issue in treating diverse microbial infections, whereas actinomycetes remain a viable source of antimicrobial natural products.
Mohamed Sebak, A. Azmy, G. Mohamed, Yasmeen Talha, Fatma Molham   +4 more
semanticscholar   +1 more source

Looking for Actives in the Haystack: Merging HRMS2-Based Molecular Networking, Chemometrics, and 13C NMR-Based Dereplication Approaches.

Journal of Natural Products
The identification of bioactive natural products (NPs) in complex mixtures has become an important subject of contemporary NP research. In an attempt to address this challenge, the present work proposes an integrated strategy that combines tandem mass ...
M. Meunier, Dimitri Bréard, S. Boisard, P. Blanchard, M. Litaudon, Khalijah Awang, A. Schinkovitz, S. Derbré   +7 more
semanticscholar   +1 more source

Identification and Dereplication of Lipopeptides from Cyanobacteria

2022
Cyanobacteria have been a focus of research as a prominent producer of secondary metabolites which possess unique activities and structural components. In this thesis, we showcase the value of dereplication strategies using untargeted MS/MS, GNPS molecular networking, NMR spectroscopy, and bioassay guided fractionation to identify known and novel ...
openaire   +1 more source