Results 251 to 260 of about 13,781 (277)

Dereplication and Partial Identification of Compounds

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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A Combined Approach for Rapid Dereplication of Herb–Drug Interaction Causative Agents in Botanical Extracts—A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe

ACS Omega
Despite promising preliminary biology, natural products isolation efforts may be confounded when the active compound is not isolated during bioassay-guided purification or classical pharmacognostic research investigations.
Suresh Chandra V A R Annam, William M. Neal, Pankaj Pandey, B. Avula, Kumar Katragunta, I. Husain, Shabana I Khan, Igor Koturbash, Bill J Gurley, Ikhlas A. Khan, A. Chittiboyina   +10 more
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Feature-based molecular networking and MS2LDA analysis for the dereplication of adjacent bis-tetrahydrofuran Annonaceous acetogenins.

Phytochemical Analysis
INTRODUCTION Annonaceous acetogenins are a group of natural polyketide compounds possessing notable cytotoxic and antitumor properties. Mass spectrometry (MS) techniques can be used for the structural determination of these compounds, including the ...
Aleksandra Gurgul, Chun-Tao Che
semanticscholar   +1 more source

On the Fly File Dereplication Mechanism

2012
Resource replication in distributed environment produces issues of secondary storage. Dereplication of resources is required when replication mechanism is hindered due to lack of secondary storage. This paper introduces dereplication approaches that depend upon last modification time, number of replica available and resource size.
Paras Gupta, Manu Vardhan, Akhil Goel, Abhinav Verma, Dharmender Singh Kushwaha   +4 more
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Dereplication of Microbial Natural Products by LC-DAD-TOFMS

Journal of Natural Products, 2011
Dereplication, the rapid identification of known compounds present in a mixture, is crucial to the fast discovery of novel natural products. Determining the elemental composition of compounds in mixtures and tentatively identifying natural products using MS/MS and UV/vis spectra is becoming easier with advances in analytical equipment and better ...
Kristian F. Nielsen, Maria Månsson, Christian Rank, Jens Christian Frisvad, and Thomas O. Larsen   +4 more
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Dereplication of calystegines in food plants and wild Solanum Brazilian fruits.

Food Chemistry
Calystegines are potent glycosidase inhibitors with therapeutic potential and are constituents of food and feed with potential toxic effects. This study aims to target calystegines and other nitrogenous substances in food plants.
L. F. L. Souto, R. Borges, Rafael Garrett da Costa, R. I. L. dos Santos, A. D. da Silva   +4 more
semanticscholar   +1 more source

Dereplication of natural products using minimal NMR data inputs

Organic & Biomolecular Chemistry, 2015
A strategy for the dereplication of a complete and a partial structure using 1H NMR, 1H–13C HSQC and 1H–1H COSY spectral data, a molecular formula composition range and structural fragments against a massive database of about 22 million compounds is considered.
Russell B, Williams, Mark, O'Neil-Johnson, Antony J, Williams, Patrick, Wheeler, Rostislav, Pol, Arvin, Moser   +5 more
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OERD - On Demand and Efficient Replication Dereplication

2012
For many years, file replication and dereplication in distributed computing environment has been researched to enhance and optimize the scalability of the entire system. Although numerous work have been proposed on the issues of file replication, a comprehensive approach still misses out on various fronts. An effort has been made in the present work to
Vardhan Manu, Gupta Paras, Kushwaha Dharmender Singh   +2 more
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Dereplication of pentacyclic triterpenoids in plants by GC‐EI/MS

Phytochemical Analysis, 2005
AbstractThree common plant‐derived pentacyclic triterpenoids, oleanolic acid (1), betulinic acid (2) and ursolic acid (3), have been found to exhibit moderate anti‐tubercular activity in a microplate alamar blue assay. In order to facilitate the discovery of novel anti‐tubercular leads with diverse chemical structures, a new and rapid GC‐EI/MS method ...
Gu J.Q., Wang Y., Franzblau S.G., Montenegro Rizzardini, Gloria, Timmermann B.N.   +4 more
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Cucurbitacins: Differential Cytotoxicity, Dereplication and First Isolation from Gonystylus keithii

Journal of Natural Products, 1994
A characteristic pattern of differential cytotoxicity of extracts of Iberis amara seeds, predominantly toward renal tumor, brain tumor, and melanoma cell lines in the NCI human disease-oriented tumor screening panel, was traced to cucurbitacins E [1] and I [2].
R W, Fuller, J H, Cardellina, G M, Cragg, M R, Boyd   +3 more
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