Results 31 to 40 of about 13,781 (277)

Modern Trends in Natural Antibiotic Discovery

Life, 2023
Natural scaffolds remain an important basis for drug development. Therefore, approaches to natural bioactive compound discovery attract significant attention. In this account, we summarize modern and emerging trends in the screening and identification of
Anna A. Baranova, Vera A. Alferova, Vladimir A. Korshun, Anton P. Tyurin   +3 more
doaj   +1 more source

A high-throughput method for dereplication and assessment of metabolite distribution in Salvia species using LC-MS/MS

Journal of Advanced Research, 2020
Dereplication of crude plant extracts through liquid chromatography-mass spectrometry is a powerful technique for the discovery of novel natural products.
Faraz Ul Haq, Arslan Ali, Naheed Akhtar, Nudrat Aziz, Muhammad Noman Khan, Manzoor Ahmad, Syed Ghulam Musharraf   +6 more
doaj   +1 more source

An Nuclear Magnetic Resonance Fingerprint Matching Approach for the Identification and Structural Re-Evaluation of Pseudomonas Lipopeptides

Microbiology Spectrum, 2022
Cyclic lipopeptides (CLiPs) are secondary metabolites secreted by a range of bacterial phyla. CLiPs from Pseudomonas in particular, display diverse structural variations in terms of the number of amino acid residues, macrocycle size, amino acid identity,
Vic De Roo, Yentl Verleysen, Benjámin Kovács, Matthias De Vleeschouwer, Penthip Muangkaew, Léa Girard, Monica Höfte, René De Mot, Annemieke Madder, Niels Geudens, José C. Martins   +10 more
doaj   +1 more source

Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine [PDF]

, 2020
The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites.
Amoozegar, Mohammad Ali, Corral Villa, Paulina, Ventosa Ucero, Antonio   +2 more
core   +1 more source

Isolation and Structural Elucidation of Compounds from Pleiocarpa bicarpellata and Their In Vitro Antiprotozoal Activity

Molecules, 2022
Species of the genus Pleiocarpa are used in traditional medicine against fever and malaria. The present study focuses on the isolation and identification of bioactive compounds from P.
Ozlem Sevik Kilicaslan, Sylvian Cretton, Luis Quirós-Guerrero, Merveilles A. Bella, Marcel Kaiser, Pascal Mäser, Joseph T. Ndongo, Muriel Cuendet   +7 more
doaj   +1 more source

Anti-cancer and antimicrobial potential of five soil Streptomycetes: a metabolomics-based study

Royal Society Open Science, 2022
Lack of new anti-cancer and anti-infective agents directed the pharmaceutical research to natural products' discovery especially from actinomycetes as one of the major sources of bioactive compounds.
Nada Osama, Walid Bakeer, Mai Raslan, Hanan A. Soliman, Usama Ramadan Abdelmohsen, Mohamed Sebak   +5 more
doaj   +1 more source

HSQCid: A Powerful Tool for Paving the Way to High-throughput Structural Dereplication of Natural Products Based on Fast NMR Experiments [PDF]

Analytical Chemistry
Structural dereplication is an essential step in the study of natural products (NPs). The number of discovered NPs is so large that efficient dereplication is highly desirable.
Bin Yuan, Chen Zhang, Chaoqun Ji, Gefeng Liu, Xiaoyi Li, Shanshan Gong, Xiangsheng Huang, Aijin Shen, Xiaonong Li, Yanfang Liu   +9 more
openalex   +2 more sources

OSMAC Strategy Integrated with Molecular Networking for Accessing Griseofulvin Derivatives from Endophytic Fungi of Moquiniastrum polymorphum (Asteraceae)

Molecules, 2021
Three endophytic fungi isolated from Moquiniastrum polymorphum (Less.) G. Sancho (Asteraceae) were cultivated using the one strain many compounds (OSMAC) strategy to evaluate the production of griseofulvin derivatives.
Victor F. Farinella, Eunizinis S. Kawafune, Marcelo M. P. Tangerina, Helori V. Domingos, Leticia V. Costa-Lotufo, Marcelo J. P. Ferreira   +5 more
doaj   +1 more source

Dereplication of microbial extracts and related analytical technologies [PDF]

The Journal of Antibiotics, 2014
Natural products still continue to have an important role as a resource of various biologically active substances. Dereplication is a key process in natural product screening that analyzes the extracts of microbial fermentation broths or plant samples.
Tatsuya, Ito, Miyako, Masubuchi
openaire   +2 more sources

Dereplication of Gambierdiscus balechii extract by LC-HRMS and in vitro assay: First description of a putative ciguatoxin and confirmation of 44-methylgambierone.

Chemosphere, 2023
Marine toxins have a significant impact on seafood resources and human health. Up to date, mainly based on bioassays results, two genera of toxic microalgae, Gambierdiscus and Fukuyoa have been hypothesized to produce a suite of biologically active ...
L. Tartaglione, Christopher R Loeffler, Valentina Miele, F. Varriale, M. Varra, Marcello Monti, Alessia Varone, Dorina Bodi, Astrid Spielmeyer, S. Capellacci, A. Penna, C. Dell’Aversano   +11 more
semanticscholar   +1 more source