Results 41 to 50 of about 13,781 (277)

Prioritization of Microorganisms Isolated from the Indian Ocean Sponge Scopalina hapalia Based on Metabolomic Diversity and Biological Activity for the Discovery of Natural Products

Microorganisms, 2023
Despite considerable advances in medicine and technology, humanity still faces many deadly diseases such as cancer and malaria. In order to find appropriate treatments, the discovery of new bioactive substances is essential.
Alexandre Le Loarer, Rémy Marcellin-Gros, Laurent Dufossé, Jérôme Bignon, Michel Frédérich, Allison Ledoux, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Anne Gauvin-Bialecki, Mireille Fouillaud   +9 more
doaj   +1 more source

6-Oxofurostane and (iso)Spirostane Types of Saponins in Smilax sieboldii: UHPLC-QToF-MS/MS and GNPS-Molecular Networking Approach for the Rapid Dereplication and Biodistribution of Specialized Metabolites

International Journal of Molecular Sciences, 2023
Identifying novel phytochemical secondary metabolites following classical pharmacognostic investigations is tedious and often involves repetitive chromatographic efforts.
B. Avula, J. Bae, Jongmin Ahn, Kumar Katragunta, Yan-Hong Wang, Mei Wang, Yongsoo Kwon, I. Khan, A. Chittiboyina   +8 more
semanticscholar   +1 more source

Applications and Restrictions of Integrated Genomic and Metabolomic Screening: An Accelerator for Drug Discovery from Actinomycetes?

Molecules, 2021
Since the golden age of antibiotics in the 1950s and 1960s actinomycetes have been the most prolific source for bioactive natural products. However, the number of discoveries of new bioactive compounds decreases since decades.
Janina Krause
doaj   +1 more source

Chemodiversity of propolis samples collected in various areas of Benin and Congo: Chromatographic profiling and chemical characterization guided by 13 C NMR dereplication.

Phytochemical Analysis, 2023
INTRODUCTION Propolis is a resinous natural substance collected by honeybees from buds and exudates of various trees and plants; it is widely accepted that the composition of propolis depends on the phytogeographic characteristics of the site of ...
F. Azonwade, Balthazar B Mabanza-Banza, Anne-Marie Le Ray, Dimitri Bréard, P. Blanchard, E. Goubalan, B. Lamine, H. Banga-Mboko, P. Richomme, S. Derbré, S. Boisard   +10 more
semanticscholar   +1 more source

Performance of a TthPrimPol-based whole genome amplification kit for copy number alteration detection using massively parallel sequencing [PDF]

, 2016
Starting from only a few cells, current whole genome amplification (WGA) methods provide enough DNA to perform massively parallel sequencing (MPS). Unfortunately, all current WGA methods introduce representation bias which limits detection of copy number
De Coninck, Dieter, De Sutter, Petra, Deforce, Dieter, Deleye, Lieselot, Dheedene, Annelies, Menten, Björn, Van Nieuwerburgh, Filip   +6 more
core   +1 more source

Dereplication of polar extracts from Croton antisyphiliticus Mart. roots and its anti-inflammatory and antinociceptive potential

Natural Product Research, 2023
Croton antisyphiliticus Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation.
J. L. S. Simão, Stéphanie V. Prado, Alan K. Pereira, G. Alexandre, Núbia Alves Mariano Teixeira Pires Gomide, Marcia Matos da Silva, D. S. Almeida, A. N. Martins, Daiany Priscilla Bueno da Silva, E. A. Costa, V. G. Pasqualotto Severino   +10 more
semanticscholar   +1 more source

Dereplication and Chemotaxonomical Studies of Marine Algae of the Ochrophyta and Rhodophyta Phyla

Marine Drugs, 2015
Dereplication and chemotaxonomic studies of six marine algae of the Ochrophyta and one of the Rhodophyta phyla resulted in the detection of 22 separate compounds.
Robert Brkljača, Emrehan Semih Gӧker, Sylvia Urban   +2 more
doaj   +1 more source

Constituents of Chamaecrista diphylla (L.) Greene Leaves with Potent Antioxidant Capacity: A Feature-Based Molecular Network Dereplication Approach

Pharmaceutics, 2021
Chamaecrista diphylla (L.) Greene (Fabaceae/Caesalpiniaceae) is a herbaceous plant that is widely distributed throughout the Americas. Plants from this genus have been used in traditional medicine as a laxative, to heal wounds, and to treat ulcers, snake
Paulo Gomes, Luis Quirós-Guerrero, Abraão Muribeca, José Reis, Sônia Pamplona, Anderson H. Lima, Mariele Trindade, Consuelo Silva, Jesus N. S. Souza, Jean A. Boutin, Jean-Luc Wolfender, Milton Silva   +11 more
doaj   +1 more source

Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges [PDF]

, 2015
Marine sponge–associated actinomycetes are considered as promising sources for the discovery of novel biologically active compounds. In the present study, a total of 64 actinomycetes were isolated from 12 different marine sponge species that had been ...
Abdelmohsen, Usama Ramadan, Cheng, Cheng, Edrada-Ebel, RuAngelie, Hentschel, Ute, Horn, Hannes, MacIntyre, Lynsey, Polymenakou, Paraskevi N.   +6 more
core   +6 more sources

UHPLC‐Q‐TOF‐MS/MS‐guided dereplication to study chemical constituents of Hedera nepalensis leaves in northern Vietnam

Journal of Analytical Science and Technology, 2023
Hedera nepalensis is commonly used as a traditional medicine for the treatment of several diseases . In this research, the efficient characterization of chemical constituents, especially triterpenoid saponins, contained in H.
P. Ngoc, Tran Chieu An, N. Hiep, Tran Phan Huynh Nhu, L. Hung, N. Q. Trung, Bui Quang Minh, Phung Van Trung   +7 more
semanticscholar   +1 more source